Assay Detail
Functional
CHEMBL4254138
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Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3M |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anticancer activity of novel water soluble benzimidazole carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.82 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 5.94 |
| CHEMBL685 | MEBENDAZOLE | 4.0 | 1 | 5.92 |
| CHEMBL1454946 | FLUBENDAZOLE | 2.0 | 1 | 5.84 |
| CHEMBL37161 | FENBENDAZOLE | 2.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL685 | MEBENDAZOLE | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1454946 | FLUBENDAZOLE | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL37161 | FENBENDAZOLE | EC50 | = | 2600.0 | nM | 5.58 |