Mitogen-activated protein kinase 14 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mitogen-activated protein kinase 14 shows late clinical disease relevance led by acute coronary syndrome. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q16539. Start with acute coronary syndrome, then reuse UniProt Q16539 as the stable protein anchor across project notes and exports.
Start with acute coronary syndrome, then reuse UniProt Q16539 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase 14 shows late clinical disease relevance led by acute coronary syndrome. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with acute coronary syndrome because it currently carries late clinical support. Linked drugs include LOSMAPIMOD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase 14
Review this target as Mitogen-activated protein kinase 14, mapped to UniProt Q16539. Sequence length is 360 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase 14 as ChEMBL target CHEMBL260, mapped to UniProt Q16539. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mitogen-activated protein kinase 14 is the right protein anchor across sources, using UniProt Q16539 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acute coronary syndrome is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Mitogen-activated protein kinase 14 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16539 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 14 |
| UniProt Accession | Q16539 |
| Component Type | Protein |
| Sequence Length | 360 aa |
Mitogen-activated protein kinase 14
Review this target as Mitogen-activated protein kinase 14, mapped to UniProt Q16539. Sequence length is 360 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase 14 shows late clinical disease relevance led by acute coronary syndrome. 5 more disease programs remain visible in the same review block.
Start review with acute coronary syndrome because it currently carries late clinical support. Linked drugs include LOSMAPIMOD. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5186216 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL3640006 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL103667 | 10.34 | Kd | 0.046 | Clinical |
| CHEMBL1088796 | 10.3 | Kd | 0.05 | Preclinical |
| CHEMBL5174953 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL5172781 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL5180443 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL1911339 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL1825148 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL1825149 | 10.1 | IC50 | 0.08 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,166 | 4,306 | 7.1 |
| assay format | 198 | 538 | 6.9 |
| cell-based format | 126 | 151 | 6.6 |
| subcellular format | 37 | 19 | 6.6 |
| tissue-based format | 6 | 56 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 120 | 6.0 |
| cell-based format | 4 | 66 | 7.1 |
| tissue-based format | 2 | 28 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |
| assay format | 1 | 0 | — |
| cell-based format | 1 | 0 | — |