Compound Detail
CHEMBL1909070
NAFENOPIN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1909070 |
| Name | NAFENOPIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XJGBDJOMWKAZJS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
4
Known Names
Molecular Properties
310.4
MW (Da)
4.40
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 2 meas. best 6.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 1 CHEMBL4040 | IC50 | 6.09 | 6.09 | 815.1 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.43 | 5.43 | 3740.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 1 | IC50 | = | 815.1 | nM | 6.09 | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: ... | - |
| Mitogen-activated protein kinase 14 | IC50 | = | 3740.5 | nM | 5.43 | DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substra... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 232 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
Data from ChEMBL 36 via Core Engine