Assay Detail
Binding
CHEMBL1909200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.01 | 6.73 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 6.73 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 6.71 |
| CHEMBL1909054 | CARBOXYMETHYLCELLULOSE | — | 2 | 6.67 |
| CHEMBL86754 | IODOQUINOL | 2.0 | 2 | 6.53 |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | — | 2 | 6.49 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 6.42 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 2 | 6.33 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 2 | 6.27 |
| CHEMBL38 | TRETINOIN | 4.0 | 2 | 6.24 |
| CHEMBL24944 | TRIBROMSALAN | 4.0 | 2 | 6.21 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | 6.16 |
| CHEMBL1909070 | NAFENOPIN | 2.0 | 2 | 6.09 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 2 | 6.05 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 2 | 5.96 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 2 | 5.91 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 5.84 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | 5.71 |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | 5.67 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 2 | 5.50 |
| CHEMBL1466 | DICUMAROL | 4.0 | 2 | 5.35 |
| CHEMBL93645 | ACECLOFENAC | 2.0 | 2 | 5.23 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 2 | 5.20 |
| CHEMBL488025 | EXISULIND | 3.0 | 2 | 4.86 |
| CHEMBL515914 | AZARIBINE | 4.0 | 2 | - |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL1909054 | CARBOXYMETHYLCELLULOSE | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | = | 320.8 | nM | 6.49 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL547 | ISOTRETINOIN | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL38 | TRETINOIN | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL24944 | TRIBROMSALAN | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL1909070 | NAFENOPIN | IC50 | = | 815.1 | nM | 6.09 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 1092.0 | nM | 5.96 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 1238.0 | nM | 5.91 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 1428.0 | nM | 5.84 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 1946.0 | nM | 5.71 |
| CHEMBL211501 | ANTIMYCIN A | IC50 | = | 2116.0 | nM | 5.67 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 3144.0 | nM | 5.50 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 4426.0 | nM | 5.35 |
| CHEMBL93645 | ACECLOFENAC | IC50 | = | 5927.0 | nM | 5.23 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 6332.0 | nM | 5.20 |
| CHEMBL488025 | EXISULIND | IC50 | = | 13825.0 | nM | 4.86 |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL1373 | MODAFINIL | Ki | - | — | - | |
| CHEMBL21731 | MAPROTILINE | Ki | - | — | - | |
| CHEMBL21731 | MAPROTILINE | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | Ki | - | — | - | |
| CHEMBL191 | LOSARTAN | IC50 | - | — | - | |
| CHEMBL534 | KETOTIFEN | Ki | - | — | - | |
| CHEMBL534 | KETOTIFEN | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | IC50 | - | — | - | |
| CHEMBL91 | MICONAZOLE | Ki | - | — | - | |
| CHEMBL1065 | METHYSERGIDE | Ki | - | — | - |