Compound Detail
CHEMBL18797
SULINDAC SULFIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL18797 |
| Name | SULINDAC SULFIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LFWHFZJPXXOYNR-MFOYZWKCSA-N |
16
Targets
41
Activities
3
Assay Types
0
PK Parameters
20
Publications
6
Known Names
Molecular Properties
340.4
MW (Da)
5.35
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.76
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Achiral |
Activity Summary
IC50 33 meas. best 7.3
Ki 5 meas. best 5.46
EC50 3 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 CHEMBL2949 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| Aldo-keto reductase family 1 member B1 CHEMBL2622 | IC50 | 7.08 | 7.08 | 84.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 7.0 | 6.345 | 100.0 | 4 |
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 6.94 | 6.55 | 115.0 | 2 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 6.1 | 6.1 | 800.0 | 2 |
| Mitogen-activated protein kinase 1 CHEMBL4040 | IC50 | 5.96 | 5.96 | 1092.0 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Prostaglandin D2 receptor 2 CHEMBL5071 | Ki | 5.46 | 5.46 | 3500.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | Ki | 5.39 | 5.39 | 4087.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | IC50 | 5.14 | 5.14 | 7231.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.92 | 4.5 | 11986.4 | 6 |
| Mu-type opioid receptor CHEMBL233 | Ki | 4.86 | 4.86 | 13667.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 4.86 | 4.86 | 13911.0 | 1 |
| Cysteinyl leukotriene receptor 1 CHEMBL1798 | Ki | 4.83 | 4.83 | 14684.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 4.62 | 4.62 | 23981.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | IC50 | 4.56 | 4.56 | 27822.0 | 1 |
| Cysteinyl leukotriene receptor 1 CHEMBL1798 | IC50 | 4.53 | 4.53 | 29368.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 4.47 | 4.47 | 33668.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.41 | 4.41 | 38700.0 | 1 |
| Gamma-secretase CHEMBL2094135 | IC50 | 4.28 | 4.2 | 53000.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine