Assay Detail
Binding
CHEMBL1909095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.79 | 7.50 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 2 | 7.50 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 2 | 7.08 |
| CHEMBL76904 | TYRPHOSTIN 23 | — | 2 | 6.70 |
| CHEMBL488025 | EXISULIND | 3.0 | 2 | 6.57 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 6.46 |
| CHEMBL15770 | SULINDAC | 4.0 | 2 | 6.36 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 2 | 5.94 |
| CHEMBL93645 | ACECLOFENAC | 2.0 | 2 | 5.89 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | 5.85 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 2 | 5.69 |
| CHEMBL1020 | TOLMETIN | 4.0 | 2 | 5.67 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 2 | 5.55 |
| CHEMBL267744 | TICRYNAFEN | 4.0 | 2 | 5.49 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 2 | 5.44 |
| CHEMBL1466 | DICUMAROL | 4.0 | 2 | 5.39 |
| CHEMBL469 | KETOROLAC | 4.0 | 2 | 5.21 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 2 | 5.03 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 2 | 4.88 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 2 | 4.77 |
| CHEMBL44 | GENISTEIN | 2.0 | 2 | 4.35 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL894 | BUPROPION | 4.0 | 2 | - |
| CHEMBL44814 | CARBON TETRACHLORIDE | -1.0 | 2 | - |
| CHEMBL277474 | ANTIPYRINE | 3.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL76904 | TYRPHOSTIN 23 | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL488025 | EXISULIND | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL15770 | SULINDAC | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL93645 | ACECLOFENAC | IC50 | = | 1288.0 | nM | 5.89 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 1414.0 | nM | 5.85 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 2038.0 | nM | 5.69 |
| CHEMBL1020 | TOLMETIN | IC50 | = | 2153.0 | nM | 5.67 |
| CHEMBL295416 | PIRINIXIC ACID | IC50 | = | 2816.9 | nM | 5.55 |
| CHEMBL267744 | TICRYNAFEN | IC50 | = | 3206.0 | nM | 5.49 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 3631.0 | nM | 5.44 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 4093.0 | nM | 5.39 |
| CHEMBL469 | KETOROLAC | IC50 | = | 6109.0 | nM | 5.21 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 9413.0 | nM | 5.03 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL421 | SULFASALAZINE | IC50 | = | 17042.0 | nM | 4.77 |
| CHEMBL44 | GENISTEIN | IC50 | = | 44979.0 | nM | 4.35 |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Ki | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL748 | PRALIDOXIME CHLORIDE | IC50 | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | - | — | - | |
| CHEMBL1909068 | — | Ki | - | — | - | |
| CHEMBL1909068 | — | IC50 | - | — | - | |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | - | — | - | |
| CHEMBL1909073 | PIPERILATE ETHOBROMIDE | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | IC50 | - | — | - | |
| CHEMBL1373 | MODAFINIL | Ki | - | — | - | |
| CHEMBL1373 | MODAFINIL | IC50 | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL1201151 | MESTRANOL | Ki | - | — | - | |
| CHEMBL1201151 | MESTRANOL | IC50 | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | Ki | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - |