Compound Detail
CHEMBL44814
CARBON TETRACHLORIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL44814 |
| Name | CARBON TETRACHLORIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VZGDMQKNWNREIO-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
17
Publications
2
Known Names
Molecular Properties
153.8
MW (Da)
2.55
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 1 meas.
IC50 1 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytochrome P450 2E1 CHEMBL5281 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cytochrome P450 2E1 | IC50 | = | 11000.0 | nM | 4.96 | DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885861 | Rattus norvegicus | 1446 |
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 1262 |
| 21459003 | 10.1016/j.bmc.2011.01.037 | HepG2 | 2 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 4 | 1 |
| 7861411 | 10.1021/jm00004a009 | Aspergillus nidulans | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 3 | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 2 | 1 |
| 23956101 | 10.1093/toxsci/kft176 | Bile salt export pump | 1 |
| 20829430 | 10.1093/toxsci/kfq269 | Bile salt export pump | 1 |
| 17629592 | 10.1016/j.ejmech.2007.05.007 | No relevant target | 1 |
| 20843939 | 10.1124/dmd.110.035113 | Hepatotoxicity | 1 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 1 |
| 20799726 | 10.1021/mp100103e | Phospholipidosis | 1 |
| 17428028 | 10.1021/ci6004542 | Phospholipidosis | 1 |
| 19056282 | 10.1016/j.bmc.2008.11.040 | ADMET | 1 |
| 2033592 | 10.1021/jm00109a021 | ADMET | 1 |
| 7861411 | 10.1021/jm00004a009 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine