Aldo-keto reductase family 1 member B1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P07943. Use UniProt P07943 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07943 as the stable identity anchor, then attach disease evidence before program review.
Aldo-keto reductase family 1 member B1
Review this target as Aldo-keto reductase family 1 member B1, mapped to UniProt P07943. Sequence length is 316 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aldo-keto reductase family 1 member B1 as ChEMBL target CHEMBL2622, mapped to UniProt P07943. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Aldo-keto reductase family 1 member B1 is the right protein anchor across sources, using UniProt P07943 as the stable mapping.
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| Preferred Name | Aldo-keto reductase family 1 member B1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P07943 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aldo-keto reductase family 1 member B1 |
| UniProt Accession | P07943 |
| Component Type | Protein |
| Sequence Length | 316 aa |
Aldo-keto reductase family 1 member B1
Review this target as Aldo-keto reductase family 1 member B1, mapped to UniProt P07943. Sequence length is 316 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL269550 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL2261578 | 8.89 | IC50 | 1.288 | Preclinical |
| CHEMBL436 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL138065 | 8.63 | IC50 | 2.36 | Preclinical |
| CHEMBL2261575 | 8.38 | IC50 | 4.169 | Preclinical |
| CHEMBL10413 | 8.36 | IC50 | 4.4 | Clinical |
| CHEMBL269455 | 8.3 | IC50 | 5.0 | Clinical |
| CHEMBL10372 | 8.3 | IC50 | 5.0 | Clinical |
| CHEMBL418832 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL363387 | 8.3 | IC50 | 5.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 200 | 700 | 5.7 |
| tissue-based format | 34 | 218 | 6.0 |
| assay format | 25 | 98 | 5.4 |
| cell-based format | 5 | 13 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 6 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 11 | 4.8 |