Assay Detail
Binding
CHEMBL1177198
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Inhibition of ovine COX1 after 5 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.22 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 1 | 7.30 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.92 |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | 4.89 |
| CHEMBL1171834 | — | — | 1 | 4.87 |
| CHEMBL1170264 | — | — | 1 | 4.77 |
| CHEMBL461883 | — | — | 1 | 4.73 |
| CHEMBL190083 | TARENFLURBIL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1316 | CARPROFEN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1171834 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL1170264 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL461883 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL190083 | TARENFLURBIL | IC50 | - | — | - |