Epidermal growth factor receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Epidermal growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 47 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00533. Start with neoplasm, then reuse UniProt P00533 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P00533 as the stable protein anchor across project notes and exports.
Epidermal growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 47 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AC-480, AMIVANTAMAB, AUMOLERTINIB, AV-412. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEpidermal growth factor receptor
Review this target as Epidermal growth factor receptor, mapped to UniProt P00533. Sequence length is 1210 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Epidermal growth factor receptor as ChEMBL target CHEMBL203, mapped to UniProt P00533. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Epidermal growth factor receptor is the right protein anchor across sources, using UniProt P00533 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 47 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Epidermal growth factor receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00533 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Epidermal growth factor receptor |
| UniProt Accession | P00533 |
| Component Type | Protein |
| Sequence Length | 1210 aa |
Epidermal growth factor receptor
Review this target as Epidermal growth factor receptor, mapped to UniProt P00533. Sequence length is 1210 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Epidermal growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AC-480, AMIVANTAMAB, AUMOLERTINIB, AV-412. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4650319 | 11.0 | IC50 | 0.01 | Approved |
| CHEMBL176582 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL5790648 | 10.8 | IC50 | 0.016 | Preclinical |
| CHEMBL5746224 | 10.77 | IC50 | 0.017 | Preclinical |
| CHEMBL5997498 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL5270693 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL4537790 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL3353410 | 10.7 | IC50 | 0.02 | Approved |
| CHEMBL180022 | 10.7 | IC50 | 0.02 | Approved |
| CHEMBL6054692 | 10.68 | IC50 | 0.021 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2,868 | 7,343 | 7.2 |
| cell-based format | 1,730 | 2,643 | 6.8 |
| assay format | 641 | 1,227 | 7.3 |
| protein format | 193 | 388 | 7.4 |
| subcellular format | 21 | 42 | 6.6 |
| cell membrane format | 9 | 38 | 6.1 |
| tissue-based format | 8 | 0 | — |
| organism-based format | 2 | 4 | 6.5 |
| cell-free format | 1 | 27 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 101 | 414 | 6.3 |
| assay format | 54 | 340 | 6.3 |
| organism-based format | 8 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 71 | 105 | 6.6 |
| assay format | 36 | 214 | 7.1 |
| single protein format | 30 | 164 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 20 | 6.9 |
| assay format | 2 | 2 | 6.4 |