Prostaglandin G/H synthase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Prostaglandin G/H synthase 1 shows approved-linked disease relevance led by Fever. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P23219. Start with Fever, then reuse UniProt P23219 as the stable protein anchor across project notes and exports.
Start with Fever, then reuse UniProt P23219 as the stable protein anchor across project notes and exports.
Prostaglandin G/H synthase 1 shows approved-linked disease relevance led by Fever. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Fever because it currently carries approved-linked support. Linked drugs include ANTIPYRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProstaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P23219. Sequence length is 599 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostaglandin G/H synthase 1 as ChEMBL target CHEMBL221, mapped to UniProt P23219. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Prostaglandin G/H synthase 1 is the right protein anchor across sources, using UniProt P23219 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Fever is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Prostaglandin G/H synthase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P23219 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 1 |
| UniProt Accession | P23219 |
| Component Type | Protein |
| Sequence Length | 599 aa |
Prostaglandin G/H synthase 1
Review this target as Prostaglandin G/H synthase 1, mapped to UniProt P23219. Sequence length is 599 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Prostaglandin G/H synthase 1 shows approved-linked disease relevance led by Fever. 5 more disease programs remain visible in the same review block.
Start review with Fever because it currently carries approved-linked support. Linked drugs include ANTIPYRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6 | 9.85 | IC50 | 0.14 | Approved |
| CHEMBL143776 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5206077 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL1945285 | 8.91 | IC50 | 1.23 | Preclinical |
| CHEMBL259972 | 8.85 | IC50 | 1.4 | Approved |
| CHEMBL75435 | 8.72 | IC50 | 1.9 | Approved |
| CHEMBL1232083 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL571 | 8.7 | IC50 | 2.0 | Approved |
| CHEMBL1034 | 8.52 | IC50 | 3.0 | Approved |
| CHEMBL139 | 8.52 | IC50 | 3.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 479 | 1,126 | 5.3 |
| tissue-based format | 79 | 280 | 5.4 |
| assay format | 60 | 100 | 5.6 |
| cell-based format | 51 | 134 | 5.8 |
| cell-free format | 18 | 58 | 5.7 |
| microsome format | 5 | 51 | 5.6 |
| organism-based format | 2 | 1 | 4.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 25 | 114 | 5.1 |
| cell-based format | 3 | 10 | 5.7 |
| tissue-based format | 3 | 0 | — |
| assay format | 1 | 0 | — |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 21 | 33 | 5.4 |
| tissue-based format | 3 | 14 | 5.0 |
| cell-based format | 2 | 15 | 5.1 |