Assay Detail
Binding
CHEMBL1909131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf21 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.10 | 8.32 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | 8.32 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 2 | 7.96 |
| CHEMBL139 | DICLOFENAC | 4.0 | 2 | 7.43 |
| CHEMBL865 | VALDECOXIB | 4.0 | 2 | 6.68 |
| CHEMBL75435 | DEXKETOPROFEN | 4.0 | 2 | 6.64 |
| CHEMBL1908355 | TENIDAP | 2.0 | 2 | 6.57 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 2 | 6.45 |
| CHEMBL469 | KETOROLAC | 4.0 | 2 | 6.37 |
| CHEMBL118 | CELECOXIB | 4.0 | 2 | 6.32 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 2 | 6.27 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 2 | 6.27 |
| CHEMBL622 | ETODOLAC | 4.0 | 2 | 6.25 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | — | 2 | 6.24 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 2 | 6.22 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 6.19 |
| CHEMBL122 | ROFECOXIB | 4.0 | 2 | 6.17 |
| CHEMBL571 | KETOPROFEN | 4.0 | 2 | 6.11 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 2 | 6.08 |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 2 | 6.04 |
| CHEMBL599 | MELOXICAM | 4.0 | 2 | 6.03 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 2 | 5.84 |
| CHEMBL456807 | PHENYLHYDRAZINE | — | 2 | 5.82 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 2 | 5.81 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 5.74 |
| CHEMBL195437 | 4-OCTYLPHENOL | — | 2 | 5.54 |
| CHEMBL1388 | MONOBENZONE | 4.0 | 2 | 5.43 |
| CHEMBL154 | NAPROXEN | 4.0 | 2 | 4.77 |
| CHEMBL521 | IBUPROFEN | 4.0 | 2 | 4.59 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 4.59 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077 | BROMFENAC | IC50 | = | 4.803 | nM | 8.32 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL75435 | DEXKETOPROFEN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1908355 | TENIDAP | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL469 | KETOROLAC | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL118 | CELECOXIB | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL622 | ETODOLAC | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL686 | MEFENAMIC ACID | IC50 | = | 602.0 | nM | 6.22 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 644.3 | nM | 6.19 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL571 | KETOPROFEN | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL63323 | NIFLUMIC ACID | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL599 | MELOXICAM | IC50 | = | 938.0 | nM | 6.03 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 1436.0 | nM | 5.84 |
| CHEMBL456807 | PHENYLHYDRAZINE | IC50 | = | 1514.0 | nM | 5.82 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 1537.0 | nM | 5.81 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 1839.0 | nM | 5.74 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 2862.0 | nM | 5.54 |
| CHEMBL1388 | MONOBENZONE | IC50 | = | 3726.0 | nM | 5.43 |
| CHEMBL154 | NAPROXEN | IC50 | = | 17001.0 | nM | 4.77 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 25844.0 | nM | 4.59 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 25530.0 | nM | 4.59 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 41796.0 | nM | 4.38 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | Ki | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | Ki | - | — | - | |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | - | — | - | |
| CHEMBL1201193 | LEVOBUPIVACAINE | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL1201151 | MESTRANOL | Ki | - | — | - | |
| CHEMBL1201151 | MESTRANOL | IC50 | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - |