Assay Detail
Binding
CHEMBL1909130
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.32 | 8.35 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75435 | DEXKETOPROFEN | 4.0 | 2 | 8.35 |
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | 8.07 |
| CHEMBL139 | DICLOFENAC | 4.0 | 2 | 7.89 |
| CHEMBL469 | KETOROLAC | 4.0 | 2 | 7.89 |
| CHEMBL571 | KETOPROFEN | 4.0 | 2 | 7.85 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 2 | 7.82 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 2 | 7.68 |
| CHEMBL1020 | TOLMETIN | 4.0 | 2 | 7.39 |
| CHEMBL1908355 | TENIDAP | 2.0 | 2 | 7.26 |
| CHEMBL175 | DEXIBUPROFEN | 4.0 | 2 | 6.98 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 2 | 6.94 |
| CHEMBL1297 | FENOPROFEN | 4.0 | 2 | 6.84 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 2 | 6.71 |
| CHEMBL509 | MECLOFENAMIC ACID | 4.0 | 2 | 6.69 |
| CHEMBL154 | NAPROXEN | 4.0 | 2 | 6.68 |
| CHEMBL521 | IBUPROFEN | 4.0 | 2 | 6.67 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | — | 2 | 6.58 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 2 | 6.46 |
| CHEMBL727 | THIOGUANINE | 4.0 | 2 | 6.22 |
| CHEMBL165 | RESVERATROL | 3.0 | 2 | 6.20 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 2 | 6.18 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 2 | 6.16 |
| CHEMBL118 | CELECOXIB | 4.0 | 2 | 6.14 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | 6.08 |
| CHEMBL1071 | OXAPROZIN | 4.0 | 2 | 6.07 |
| CHEMBL413965 | FELBINAC | 3.0 | 2 | 6.05 |
| CHEMBL1388 | MONOBENZONE | 4.0 | 2 | 5.99 |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 2 | 5.97 |
| CHEMBL302795 | TENOXICAM | 2.0 | 2 | 5.94 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 2 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75435 | DEXKETOPROFEN | IC50 | = | 4.483 | nM | 8.35 |
| CHEMBL1077 | BROMFENAC | IC50 | = | 8.481 | nM | 8.07 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL469 | KETOROLAC | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL571 | KETOPROFEN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1020 | TOLMETIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1908355 | TENIDAP | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL175 | DEXIBUPROFEN | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL686 | MEFENAMIC ACID | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1297 | FENOPROFEN | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL509 | MECLOFENAMIC ACID | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL154 | NAPROXEN | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL165 | RESVERATROL | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 688.0 | nM | 6.16 |
| CHEMBL118 | CELECOXIB | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL1071 | OXAPROZIN | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL413965 | FELBINAC | IC50 | = | 894.0 | nM | 6.05 |
| CHEMBL1388 | MONOBENZONE | IC50 | = | 1019.0 | nM | 5.99 |
| CHEMBL63323 | NIFLUMIC ACID | IC50 | = | 1064.0 | nM | 5.97 |
| CHEMBL302795 | TENOXICAM | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 1226.0 | nM | 5.91 |
| CHEMBL527 | PIROXICAM | IC50 | = | 1313.0 | nM | 5.88 |
| CHEMBL599 | MELOXICAM | IC50 | = | 1319.0 | nM | 5.88 |
| CHEMBL294199 | CAPSAICIN | IC50 | = | 1551.0 | nM | 5.81 |
| CHEMBL24944 | TRIBROMSALAN | IC50 | = | 2065.0 | nM | 5.68 |
| CHEMBL622 | ETODOLAC | IC50 | = | 2649.0 | nM | 5.58 |
| CHEMBL165790 | IPRIFLAVONE | IC50 | = | 2944.3 | nM | 5.53 |
| CHEMBL1612004 | — | IC50 | = | 3152.0 | nM | 5.50 |
| CHEMBL526 | PROPOFOL | IC50 | = | 3832.0 | nM | 5.42 |
| CHEMBL1105 | 6-METHOXY-2-NAPHTHYLACETIC ACID | IC50 | = | 4113.0 | nM | 5.39 |
| CHEMBL25 | ASPIRIN | IC50 | = | 4192.0 | nM | 5.38 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 4391.0 | nM | 5.36 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 10319.0 | nM | 4.99 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 16242.0 | nM | 4.79 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 31868.0 | nM | 4.50 |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL1909068 | — | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - |