Carbonic anhydrase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Carbonic anhydrase 1 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00915. Start with glaucoma, then reuse UniProt P00915 as the stable protein anchor across project notes and exports.
Start with glaucoma, then reuse UniProt P00915 as the stable protein anchor across project notes and exports.
Carbonic anhydrase 1 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with glaucoma because it currently carries approved-linked support. Linked drugs include ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM, DICHLORPHENAMIDE, METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCarbonic anhydrase 1
Review this target as Carbonic anhydrase 1, mapped to UniProt P00915. Sequence length is 261 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Carbonic anhydrase 1 as ChEMBL target CHEMBL261, mapped to UniProt P00915. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Carbonic anhydrase 1 is the right protein anchor across sources, using UniProt P00915 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why glaucoma is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Carbonic anhydrase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00915 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Carbonic anhydrase 1 |
| UniProt Accession | P00915 |
| Component Type | Protein |
| Sequence Length | 261 aa |
Carbonic anhydrase 1
Review this target as Carbonic anhydrase 1, mapped to UniProt P00915. Sequence length is 261 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Carbonic anhydrase 1 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block.
Start review with glaucoma because it currently carries approved-linked support. Linked drugs include ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM, DICHLORPHENAMIDE, METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3608873 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL3608874 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL3797893 | 10.54 | Kd | 0.029 | Preclinical |
| CHEMBL2333418 | 10.48 | Kd | 0.033 | Preclinical |
| CHEMBL3585779 | 10.34 | Ki | 0.0459 | Preclinical |
| CHEMBL3585777 | 10.32 | Ki | 0.0483 | Preclinical |
| CHEMBL3608890 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL2333816 | 10.3 | Kd | 0.05 | Preclinical |
| CHEMBL2333397 | 10.3 | Kd | 0.05 | Preclinical |
| CHEMBL2333409 | 10.17 | Kd | 0.067 | Preclinical |