Compound Detail
CHEMBL406
INDAPAMIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL406 |
| Name | INDAPAMIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | NDDAHWYSQHTHNT-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
14
Targets
55
Activities
3
Assay Types
2
PK Parameters
20
Publications
30
Known Names
7
Indications
1
Mechanisms
Molecular Properties
365.8
MW (Da)
2.08
ALogP
4
HBA
2
HBD
92.5
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1983 |
| Availability | Prescription |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Thiazide-sensitive sodium-chloride cotransporter inhibitor | INHIBITOR | Solute carrier family 12 member 3 | ✓ | ✓ |
Indications
Cardiovascular Diseases Heart Failure Hypertension Toxemia Diabetes Mellitus, Type 2 Essential Hypertension Multiple Sclerosis, Chronic Progressive
ATC Classification
C03BA11
indapamide
Level 1: CARDIOVASCULAR SYSTEM
Level 2: DIURETICS
Activity Summary
Kd 40 meas. best 9.48
Ki 13 meas. best 9.64
IC50 2 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Carbonic anhydrase 7 CHEMBL2326 | Ki | 9.64 | 9.64 | 0.2 | 2 |
| Carbonic anhydrase 4 CHEMBL3729 | Kd | 9.48 | 8.295 | 0.3 | 2 |
| Carbonic anhydrase 14 CHEMBL3510 | Kd | 9.42 | 8.31 | 0.4 | 2 |
| Carbonic anhydrase 5B, mitochondrial CHEMBL3969 | Kd | 9.34 | 8.285 | 0.5 | 2 |
| Carbonic anhydrase 6 CHEMBL3025 | Kd | 9.0 | 7.25 | 1.0 | 3 |
| Carbonic anhydrase 7 CHEMBL2326 | Kd | 8.84 | 6.846 | 1.5 | 5 |
| Carbonic anhydrase 9 CHEMBL3594 | Kd | 8.69 | 7.53 | 2.0 | 2 |
| Carbonic anhydrase 2 CHEMBL205 | Kd | 8.42 | 6.74 | 3.8 | 7 |
| Carbonic anhydrase 13 CHEMBL3912 | Kd | 8.39 | 7.126 | 4.1 | 5 |
| Carbonic anhydrase 5A, mitochondrial CHEMBL4789 | Kd | 8.16 | 7.165 | 7.0 | 2 |
| Carbonic anhydrase 12 CHEMBL3242 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Carbonic anhydrase 12 CHEMBL3242 | Kd | 7.91 | 6.4867 | 12.2 | 3 |
| Carbonic anhydrase 13 CHEMBL2186 | Ki | 7.89 | 7.89 | 13.0 | 1 |
| Carbonic anhydrase 9 CHEMBL3594 | Ki | 7.44 | 7.44 | 36.0 | 1 |
| Carbonic anhydrase 3 CHEMBL2885 | Kd | 6.98 | 5.4967 | 105.0 | 3 |
| Carbonic anhydrase 4 CHEMBL3729 | Ki | 6.67 | 6.67 | 213.0 | 1 |
| Carbonic anhydrase 1 CHEMBL261 | Kd | 6.58 | 5.3325 | 261.0 | 4 |
| Carbonic anhydrase 5B, mitochondrial CHEMBL3969 | Ki | 6.56 | 6.56 | 274.0 | 1 |
| Carbonic anhydrase 5A, mitochondrial CHEMBL4789 | Ki | 6.05 | 6.05 | 890.0 | 1 |
| Carbonic anhydrase 6 CHEMBL3025 | Ki | 5.79 | 5.79 | 1606.0 | 1 |
| Carbonic anhydrase 2 CHEMBL205 | Ki | 5.6 | 5.6 | 2520.0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 CHEMBL4358 | IC50 | 5.54 | 5.54 | 2918.0 | 1 |
| Carbonic anhydrase 14 CHEMBL3510 | Ki | 5.3 | 5.3 | 4950.0 | 1 |
| Carbonic anhydrase 1 CHEMBL261 | Ki | 4.29 | 4.29 | 51900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 4.9 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 13.18 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine