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Target Snapshot

CHEMBL3969 Target Snapshot

Carbonic anhydrase 5B, mitochondrial · SINGLE PROTEIN · Homo sapiens

746Compounds
84Assays
27Approved Drugs
894.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9Y2D0. Use UniProt Q9Y2D0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y2D0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 5B, mitochondrial as ChEMBL target CHEMBL3969, mapped to UniProt Q9Y2D0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 5B, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3969
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y2D0
Carbonic anhydrase 5B, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 5B, mitochondrial is the right protein anchor across sources, using UniProt Q9Y2D0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 5B, mitochondrial
UniProt AccessionQ9Y2D0
Component TypeProtein
Sequence Length317 aa

Carbonic anhydrase 5B, mitochondrial

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase 5B, mitochondrial, mapped to UniProt Q9Y2D0. Sequence length is 317 aa.

Mapped IDQ9Y2D0
Review nameCarbonic anhydrase 5B, mitochondrial
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

27
Approved
10
Phase III
6
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC501.0
KI534.0
KD359.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4446052 11.0 Kd 0.01 Preclinical
CHEMBL4444784 10.96 Kd 0.011 Preclinical
CHEMBL4555586 10.96 Kd 0.011 Preclinical
CHEMBL4555622 10.96 Kd 0.011 Preclinical
CHEMBL4463683 10.92 Kd 0.012 Preclinical
CHEMBL4473602 10.8 Kd 0.016 Preclinical
CHEMBL4451503 10.7 Kd 0.02 Preclinical
CHEMBL4551069 10.7 Kd 0.02 Preclinical
CHEMBL4539340 10.6 Kd 0.025 Preclinical
CHEMBL4444201 10.52 Kd 0.03 Preclinical
Distribution

pChEMBL Value Distribution

83
5.0
40
5.5
82
6.0
49
6.5
203
7.0
120
7.5
72
8.0
36
8.5
34
9.0
26
9.5
pChEMBL
Approved Drugs

Approved Drugs

LACOSAMIDE
CHEMBL58323
Approved 2008
VALDECOXIB
CHEMBL865
Approved 2001
BRINZOLAMIDE
CHEMBL220491
Approved 1998
CELECOXIB
CHEMBL118
Approved 1998
TOPIRAMATE
CHEMBL220492
Approved 1996
DORZOLAMIDE
CHEMBL218490
Approved 1994
INDAPAMIDE
CHEMBL406
Approved 1983
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
DOBUTAMINE
CHEMBL926
Approved 1978
FUROSEMIDE
CHEMBL35
Approved 1966
CHLORTHALIDONE
CHEMBL1055
Approved 1960
TRICHLORMETHIAZIDE
CHEMBL1054
Approved 1960
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

84
Total Assays
542
Tested Compounds
2
Assay Types
Binding — 83 assays, 542 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 73 390 6.8
assay format 10 152 8.0
ADME — 1 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 23 7.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine