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Target Snapshot

CHEMBL2326 Target Snapshot

Carbonic anhydrase 7 · SINGLE PROTEIN · Homo sapiens

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1,876Compounds
180Assays
31Approved Drugs
2,276.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Carbonic anhydrase 7 shows approved-linked disease relevance led by glaucoma. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P43166. Start with glaucoma, then reuse UniProt P43166 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with glaucoma, then reuse UniProt P43166 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
glaucoma

Carbonic anhydrase 7 shows approved-linked disease relevance led by glaucoma. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with glaucoma because it currently carries approved-linked support. Linked drugs include METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 7 as ChEMBL target CHEMBL2326, mapped to UniProt P43166. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 7
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2326
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P43166
Carbonic anhydrase 7
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 7 is the right protein anchor across sources, using UniProt P43166 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why glaucoma is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCarbonic anhydrase 7
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP43166
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 7
UniProt AccessionP43166
Component TypeProtein
Sequence Length264 aa

Carbonic anhydrase 7

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Carbonic anhydrase 7, mapped to UniProt P43166. Sequence length is 264 aa.

Mapped IDP43166
Review nameCarbonic anhydrase 7
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Carbonic anhydrase 7 shows approved-linked disease relevance led by glaucoma. 4 more disease programs remain visible in the same review block.

Approved-linked Approved
glaucoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHAZOLAMIDE
Approved-linked Approved
open-angle glaucoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHAZOLAMIDE
Clinical signal Phase II
cervical cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHAZOLAMIDE
Clinical signal Phase II
essential tremor
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHAZOLAMIDE
Clinical signal Phase I
altitude sickness
1 linked drug · 1 direct · 1 efficacy
Linked drugMETHAZOLAMIDE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with glaucoma because it currently carries approved-linked support. Linked drugs include METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseglaucoma
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

31
Approved
10
Phase III
11
Phase II
3
Phase I
2
Phase 0.5
Assay Mix

Activity Type Distribution

IC506.0
KI1,643.0
KD627.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4442511 11.0 Kd 0.01 Preclinical
CHEMBL4444201 11.0 Kd 0.01 Preclinical
CHEMBL4450306 11.0 Kd 0.01 Preclinical
CHEMBL4456084 11.0 Kd 0.01 Preclinical
CHEMBL4515586 11.0 Kd 0.01 Preclinical
CHEMBL4539233 11.0 Kd 0.01 Preclinical
CHEMBL4572161 11.0 Kd 0.01 Preclinical
CHEMBL4588838 11.0 Kd 0.01 Preclinical
CHEMBL4592616 11.0 Kd 0.01 Preclinical
CHEMBL4461481 10.92 Kd 0.012 Preclinical
Distribution

pChEMBL Value Distribution

147
5.0
66
5.5
216
6.0
168
6.5
383
7.0
230
7.5
341
8.0
200
8.5
134
9.0
62
9.5
pChEMBL
Approved Drugs

Approved Drugs

NILOTINIB
CHEMBL255863
Approved 2007
Properties Compare Identifier
IMATINIB
CHEMBL941
Approved 2001
Properties Compare Identifier
ZONISAMIDE
CHEMBL750
Approved 2000
Properties Compare Identifier
BRINZOLAMIDE
CHEMBL220491
Approved 1998
Properties Compare Identifier
TOPIRAMATE
CHEMBL220492
Approved 1996
Properties Compare Identifier
DORZOLAMIDE
CHEMBL218490
Approved 1994
Properties Compare Identifier
FAMOTIDINE
CHEMBL902
Approved 1986
Properties Compare Identifier
SULFANILAMIDE
CHEMBL21
Approved 1985
Properties Compare Identifier
INDAPAMIDE
CHEMBL406
Approved 1983
Properties Compare Identifier
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
Properties Compare Identifier
METOLAZONE
CHEMBL878
Approved 1973
Properties Compare Identifier
MAFENIDE
CHEMBL419
Approved 1969
Properties Compare Identifier
FUROSEMIDE
CHEMBL35
Approved 1966
Properties Compare Identifier
CHLORTHALIDONE
CHEMBL1055
Approved 1960
Properties Compare Identifier
TRICHLORMETHIAZIDE
CHEMBL1054
Approved 1960
Properties Compare Identifier
METHAZOLAMIDE
CHEMBL19
Approved 1959
Properties Compare Identifier
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
Properties Compare Identifier
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

180
Total Assays
1,537
Tested Compounds
2
Assay Types
Binding — 176 assays, 1,537 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 160 1,404 7.4
assay format 15 133 8.6
tissue-based format 1 0 —
ADME — 4 assays, 65 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 20 7.2
single protein format 2 45 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine