Use UniProt P35218 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4789 Target Snapshot
Carbonic anhydrase 5A, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P35218. Use UniProt P35218 as the stable identity anchor, then attach disease evidence before program review.
Carbonic anhydrase 5A, mitochondrial
Review this target as Carbonic anhydrase 5A, mitochondrial, mapped to UniProt P35218. Sequence length is 305 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Carbonic anhydrase 5A, mitochondrial as ChEMBL target CHEMBL4789, mapped to UniProt P35218. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Carbonic anhydrase 5A, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35218 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Carbonic anhydrase 5A, mitochondrial |
| UniProt Accession | P35218 |
| Component Type | Protein |
| Sequence Length | 305 aa |
Carbonic anhydrase 5A, mitochondrial
How to read this target
Review this target as Carbonic anhydrase 5A, mitochondrial, mapped to UniProt P35218. Sequence length is 305 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4205449 | 10.7 | Kd | 0.02 | Preclinical |
| CHEMBL4207063 | 10.22 | Kd | 0.06 | Preclinical |
| CHEMBL4214894 | 10.15 | Kd | 0.07 | Preclinical |
| CHEMBL4474833 | 9.96 | Kd | 0.11 | Preclinical |
| CHEMBL4210750 | 9.85 | Kd | 0.14 | Preclinical |
| CHEMBL4204729 | 9.85 | Kd | 0.14 | Preclinical |
| CHEMBL1272187 | 9.6 | Kd | 0.25 | Preclinical |
| CHEMBL4474251 | 9.46 | Kd | 0.35 | Preclinical |
| CHEMBL4439909 | 9.34 | Kd | 0.46 | Preclinical |
| CHEMBL4207242 | 9.33 | Kd | 0.47 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 108 assays, 671 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 96 | 557 | 6.5 |
| assay format | 12 | 114 | 6.8 |
ADME — 1 assays, 23 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 23 | 7.0 |