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Target Snapshot

CHEMBL4789 Target Snapshot

Carbonic anhydrase 5A, mitochondrial · SINGLE PROTEIN · Homo sapiens

877Compounds
109Assays
36Approved Drugs
1,109.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P35218. Use UniProt P35218 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35218 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 5A, mitochondrial as ChEMBL target CHEMBL4789, mapped to UniProt P35218. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 5A, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4789
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35218
Carbonic anhydrase 5A, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 5A, mitochondrial is the right protein anchor across sources, using UniProt P35218 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 5A, mitochondrial
UniProt AccessionP35218
Component TypeProtein
Sequence Length305 aa

Carbonic anhydrase 5A, mitochondrial

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase 5A, mitochondrial, mapped to UniProt P35218. Sequence length is 305 aa.

Mapped IDP35218
Review nameCarbonic anhydrase 5A, mitochondrial
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

36
Approved
11
Phase III
7
Phase II
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC5044.0
KI702.0
KD363.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4205449 10.7 Kd 0.02 Preclinical
CHEMBL4207063 10.22 Kd 0.06 Preclinical
CHEMBL4214894 10.15 Kd 0.07 Preclinical
CHEMBL4474833 9.96 Kd 0.11 Preclinical
CHEMBL4210750 9.85 Kd 0.14 Preclinical
CHEMBL4204729 9.85 Kd 0.14 Preclinical
CHEMBL1272187 9.6 Kd 0.25 Preclinical
CHEMBL4474251 9.46 Kd 0.35 Preclinical
CHEMBL4439909 9.34 Kd 0.46 Preclinical
CHEMBL4207242 9.33 Kd 0.47 Preclinical
Distribution

pChEMBL Value Distribution

138
5.0
73
5.5
133
6.0
71
6.5
258
7.0
73
7.5
55
8.0
15
8.5
10
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

LENVATINIB
CHEMBL1289601
Approved 2015
RUFINAMIDE
CHEMBL1201754
Approved 2007
VALDECOXIB
CHEMBL865
Approved 2001
ZONISAMIDE
CHEMBL750
Approved 2000
BRINZOLAMIDE
CHEMBL220491
Approved 1998
CELECOXIB
CHEMBL118
Approved 1998
TOPIRAMATE
CHEMBL220492
Approved 1996
DORZOLAMIDE
CHEMBL218490
Approved 1994
FLUDARABINE PHOSPHATE
CHEMBL1096882
Approved 1991
INDAPAMIDE
CHEMBL406
Approved 1983
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
DOBUTAMINE
CHEMBL926
Approved 1978
FUROSEMIDE
CHEMBL35
Approved 1966
TRICHLORMETHIAZIDE
CHEMBL1054
Approved 1960
CHLORTHALIDONE
CHEMBL1055
Approved 1960
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

109
Total Assays
671
Tested Compounds
2
Assay Types
Binding — 108 assays, 671 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 96 557 6.5
assay format 12 114 6.8
ADME — 1 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 23 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine