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Evidence Snapshot

Carbonic anhydrase 5A, mitochondrial

CHEMBL4789 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:24:30Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4789
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 5A, mitochondrial as ChEMBL target CHEMBL4789, mapped to UniProt P35218. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 5A, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4789
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35218
Carbonic anhydrase 5A, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Carbonic anhydrase 5A, mitochondrial matters

As of 2026-09-13

Carbonic anhydrase 5A, mitochondrial is reviewed as Carbonic anhydrase 5A, mitochondrial (UniProt P35218); the current evidence base includes 36 approved drugs, 877 compounds, and 109 assays, with lead potency reaching pChEMBL 10.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 36 approved drugs, 877 compounds, and 109 assays for this target. The dominant activity type is KI. CHEMBL4205449 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL4205449 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
36 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Carbonic anhydrase 5A, mitochondrial matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P35218, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

877
Total Compounds
109
Total Assays
36
Approved Drugs
IC50: 44.0, KI: 702.0, KD: 363.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4205449
 10.7 Kd —
No preferred name
CHEMBL4207063
 10.2 Kd —
No preferred name
CHEMBL4214894
 10.2 Kd —
No preferred name
CHEMBL4474833
 10.0 Kd —
No preferred name
CHEMBL4210750
 9.8 Kd —

Approved Drugs

Structure Compound First Approval
LENVATINIB
CHEMBL1289601
 2015
RUFINAMIDE
CHEMBL1201754
 2007
VALDECOXIB
CHEMBL865
 2001
ZONISAMIDE
CHEMBL750
 2000
BRINZOLAMIDE
CHEMBL220491
 1998
CELECOXIB
CHEMBL118
 1998
TOPIRAMATE
CHEMBL220492
 1996
DORZOLAMIDE
CHEMBL218490
 1994
FLUDARABINE PHOSPHATE
CHEMBL1096882
 1991
INDAPAMIDE
CHEMBL406
 1983
ETHOXZOLAMIDE
CHEMBL18
 1982
DOBUTAMINE
CHEMBL926
 1978
FUROSEMIDE
CHEMBL35
 1966
TRICHLORMETHIAZIDE
CHEMBL1054
 1960
CHLORTHALIDONE
CHEMBL1055
 1960
METHAZOLAMIDE
CHEMBL19
 1959
DICHLORPHENAMIDE
CHEMBL17
 1958
ACETAZOLAMIDE
CHEMBL20
 1953
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:24:30Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4789