Assay Detail
Binding
CHEMBL2446501
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Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 43 | 7.13 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443190 | — | — | 1 | 8.90 |
| CHEMBL2443192 | — | — | 1 | 8.74 |
| CHEMBL2443206 | — | — | 1 | 8.68 |
| CHEMBL2010994 | — | — | 1 | 8.46 |
| CHEMBL2443200 | — | — | 1 | 8.30 |
| CHEMBL2443204 | — | — | 1 | 8.00 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL2010990 | — | — | 1 | 7.89 |
| CHEMBL2443188 | — | — | 1 | 7.78 |
| CHEMBL2011153 | — | — | 1 | 7.64 |
| CHEMBL2443196 | — | — | 1 | 7.60 |
| CHEMBL2010993 | — | — | 1 | 7.60 |
| CHEMBL2011154 | — | — | 1 | 7.54 |
| CHEMBL2011000 | — | — | 1 | 7.54 |
| CHEMBL2443194 | — | — | 1 | 7.48 |
| CHEMBL2010989 | — | — | 1 | 7.38 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL2010991 | — | — | 1 | 7.25 |
| CHEMBL2010992 | — | — | 1 | 7.20 |
| CHEMBL2010807 | — | — | 1 | 7.18 |
| CHEMBL2011152 | — | — | 1 | 7.17 |
| CHEMBL2443202 | — | — | 1 | 7.11 |
| CHEMBL2010998 | — | — | 1 | 7.08 |
| CHEMBL2443198 | — | — | 1 | 7.08 |
| CHEMBL406 | INDAPAMIDE | 4.0 | 1 | 7.00 |
| CHEMBL2010999 | — | — | 1 | 6.96 |
| CHEMBL2010995 | — | — | 1 | 6.90 |
| CHEMBL2011156 | — | — | 1 | 6.90 |
| CHEMBL2443201 | — | — | 1 | 6.78 |
| CHEMBL2010987 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443190 | — | Kd | = | 1.25 | nM | 8.90 |
| CHEMBL2443192 | — | Kd | = | 1.82 | nM | 8.74 |
| CHEMBL2443206 | — | Kd | = | 2.08 | nM | 8.68 |
| CHEMBL2010994 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL2443200 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL2443204 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL18 | ETHOXZOLAMIDE | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL2010990 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL2443188 | — | Kd | = | 16.7 | nM | 7.78 |
| CHEMBL2011153 | — | Kd | = | 22.7 | nM | 7.64 |
| CHEMBL2443196 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL2010993 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL2011154 | — | Kd | = | 28.6 | nM | 7.54 |
| CHEMBL2011000 | — | Kd | = | 28.6 | nM | 7.54 |
| CHEMBL2443194 | — | Kd | = | 33.3 | nM | 7.48 |
| CHEMBL2010989 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL2010991 | — | Kd | = | 55.6 | nM | 7.25 |
| CHEMBL2010992 | — | Kd | = | 62.5 | nM | 7.20 |
| CHEMBL2010807 | — | Kd | = | 66.7 | nM | 7.18 |
| CHEMBL2011152 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL2443202 | — | Kd | = | 76.9 | nM | 7.11 |
| CHEMBL2443198 | — | Kd | = | 83.3 | nM | 7.08 |
| CHEMBL2010998 | — | Kd | = | 83.3 | nM | 7.08 |
| CHEMBL406 | INDAPAMIDE | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2010999 | — | Kd | = | 111.0 | nM | 6.96 |
| CHEMBL2010995 | — | Kd | = | 125.0 | nM | 6.90 |
| CHEMBL2011156 | — | Kd | = | 125.0 | nM | 6.90 |
| CHEMBL2443201 | — | Kd | = | 167.0 | nM | 6.78 |
| CHEMBL2010987 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL2443193 | — | Kd | = | 278.0 | nM | 6.56 |
| CHEMBL2010996 | — | Kd | = | 286.0 | nM | 6.54 |
| CHEMBL2443191 | — | Kd | = | 333.0 | nM | 6.48 |
| CHEMBL2010997 | — | Kd | = | 333.0 | nM | 6.48 |
| CHEMBL2011155 | — | Kd | = | 333.0 | nM | 6.48 |
| CHEMBL2010988 | — | Kd | = | 357.0 | nM | 6.45 |
| CHEMBL2443207 | — | Kd | = | 556.0 | nM | 6.25 |
| CHEMBL2443199 | — | Kd | = | 833.0 | nM | 6.08 |
| CHEMBL2443205 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2443189 | — | Kd | = | 1330.0 | nM | 5.88 |
| CHEMBL2443197 | — | Kd | = | 1430.0 | nM | 5.84 |
| CHEMBL2443195 | — | Kd | = | 1570.0 | nM | 5.80 |
| CHEMBL2443203 | — | Kd | = | 2220.0 | nM | 5.65 |