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Target Snapshot

CHEMBL3729 Target Snapshot

Carbonic anhydrase 4 · SINGLE PROTEIN · Homo sapiens

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1,992Compounds
170Assays
36Approved Drugs
2,252.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Carbonic anhydrase 4 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P22748. Start with glaucoma, then reuse UniProt P22748 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with glaucoma, then reuse UniProt P22748 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 4 linked drugs
Open source guide
Disease program
glaucoma

Carbonic anhydrase 4 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.

Start review with glaucoma because it currently carries approved-linked support. Linked drugs include ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM, DICHLORPHENAMIDE, METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 4 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 4 as ChEMBL target CHEMBL3729, mapped to UniProt P22748. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3729
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P22748
Carbonic anhydrase 4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 4 is the right protein anchor across sources, using UniProt P22748 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why glaucoma is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCarbonic anhydrase 4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP22748
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 4
UniProt AccessionP22748
Component TypeProtein
Sequence Length312 aa

Carbonic anhydrase 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Carbonic anhydrase 4, mapped to UniProt P22748. Sequence length is 312 aa.

Mapped IDP22748
Review nameCarbonic anhydrase 4
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Carbonic anhydrase 4 shows approved-linked disease relevance led by glaucoma. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
glaucoma
4 linked drugs · 4 direct · 4 efficacy
Linked drugACETAZOLAMIDE
Linked drugACETAZOLAMIDE SODIUM
Linked drugDICHLORPHENAMIDE
Linked drugMETHAZOLAMIDE
Approved-linked Approved
Seizure
3 linked drugs · 3 direct · 3 efficacy
Linked drugACETAZOLAMIDE
Linked drugACETAZOLAMIDE SODIUM
Linked drugTOPIRAMATE
Approved-linked Approved
altitude sickness
2 linked drugs · 2 direct · 2 efficacy
Linked drugACETAZOLAMIDE
Linked drugMETHAZOLAMIDE
Approved-linked Approved
angle-closure glaucoma
2 linked drugs · 2 direct · 2 efficacy
Linked drugACETAZOLAMIDE
Linked drugACETAZOLAMIDE SODIUM
Approved-linked Approved
edema
2 linked drugs · 2 direct · 2 efficacy
Linked drugACETAZOLAMIDE
Linked drugACETAZOLAMIDE SODIUM
Approved-linked Approved
epilepsy
2 linked drugs · 2 direct · 2 efficacy
Linked drugACETAZOLAMIDE
Linked drugTOPIRAMATE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with glaucoma because it currently carries approved-linked support. Linked drugs include ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM, DICHLORPHENAMIDE, METHAZOLAMIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseglaucoma
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

36
Approved
9
Phase III
11
Phase II
2
Phase I
2
Phase 0.5
Assay Mix

Activity Type Distribution

IC5040.0
KI1,866.0
KD346.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4451500 11.0 Kd 0.01 Preclinical
CHEMBL4569008 11.0 Kd 0.01 Preclinical
CHEMBL4584546 11.0 Kd 0.01 Preclinical
CHEMBL4562296 10.7 Kd 0.02 Preclinical
CHEMBL4572161 10.7 Kd 0.02 Preclinical
CHEMBL4173471 10.52 Kd 0.03 Preclinical
CHEMBL4450456 10.52 Kd 0.03 Preclinical
CHEMBL4450545 10.52 Kd 0.03 Preclinical
CHEMBL4593681 10.52 Kd 0.03 Preclinical
CHEMBL4166964 10.4 Kd 0.04 Preclinical
Distribution

pChEMBL Value Distribution

348
5.0
207
5.5
344
6.0
203
6.5
347
7.0
93
7.5
128
8.0
47
8.5
63
9.0
47
9.5
pChEMBL
Approved Drugs

Approved Drugs

LACOSAMIDE
CHEMBL58323
Approved 2008
Properties Compare Identifier
NILOTINIB
CHEMBL255863
Approved 2007
Properties Compare Identifier
VALDECOXIB
CHEMBL865
Approved 2001
Properties Compare Identifier
BRINZOLAMIDE
CHEMBL220491
Approved 1998
Properties Compare Identifier
CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
DORZOLAMIDE
CHEMBL218490
Approved 1994
Properties Compare Identifier
FAMOTIDINE
CHEMBL902
Approved 1986
Properties Compare Identifier
INDAPAMIDE
CHEMBL406
Approved 1983
Properties Compare Identifier
SODIUM CITRATE
CHEMBL1355
Approved 1983
Properties Compare Identifier
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
Properties Compare Identifier
FUROSEMIDE
CHEMBL35
Approved 1966
Properties Compare Identifier
CHLORTHALIDONE
CHEMBL1055
Approved 1960
Properties Compare Identifier
TRICHLORMETHIAZIDE
CHEMBL1054
Approved 1960
Properties Compare Identifier
METHAZOLAMIDE
CHEMBL19
Approved 1959
Properties Compare Identifier
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
Properties Compare Identifier
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

170
Total Assays
1,588
Tested Compounds
3
Assay Types
Binding — 163 assays, 1,588 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 143 1,348 6.4
assay format 20 240 7.5
ADME — 6 assays, 90 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 70 5.9
assay format 2 20 7.2
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine