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Assay Detail

CHEMBL1909185

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type U-937
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.36 6.56
Ki 871 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1016 CANDESARTAN 3.0 2 6.56
CHEMBL19224 PAPAVERINE 3.0 2 6.09
CHEMBL388590 BENZBROMARONE 4.0 2 5.98
CHEMBL506247 TANNIC ACID 4.0 2 5.98
CHEMBL932 DIPYRIDAMOLE 4.0 2 5.80
CHEMBL283196 ALPHA-NAPHTHOFLAVONE — 2 5.54
CHEMBL1619 CLADRIBINE 4.0 2 5.44
CHEMBL964 DISULFIRAM 4.0 2 5.32
CHEMBL434063 — — 2 5.13
CHEMBL118 CELECOXIB 4.0 2 5.03
CHEMBL98350 LY-294002 -1.0 2 4.98
CHEMBL44 GENISTEIN 2.0 2 4.96
CHEMBL18701 RO-201724 — 2 4.95
CHEMBL10 SB-203580 — 2 4.94
CHEMBL1909069 — — 2 4.65
CHEMBL193 NIFEDIPINE 4.0 2 4.36
CHEMBL515914 AZARIBINE 4.0 2 -
CHEMBL1200558 BACITRACIN 4.0 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL894 BUPROPION 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1016 CANDESARTAN IC50 = 276.1 nM 6.56
CHEMBL19224 PAPAVERINE IC50 = 817.0 nM 6.09
CHEMBL506247 TANNIC ACID IC50 = 1043.0 nM 5.98
CHEMBL388590 BENZBROMARONE IC50 = 1056.0 nM 5.98
CHEMBL932 DIPYRIDAMOLE IC50 = 1579.0 nM 5.80
CHEMBL283196 ALPHA-NAPHTHOFLAVONE IC50 = 2919.7 nM 5.54
CHEMBL1619 CLADRIBINE IC50 = 3625.0 nM 5.44
CHEMBL964 DISULFIRAM IC50 = 4799.0 nM 5.32
CHEMBL434063 — IC50 = 7450.0 nM 5.13
CHEMBL118 CELECOXIB IC50 = 9260.0 nM 5.03
CHEMBL98350 LY-294002 IC50 = 10404.0 nM 4.98
CHEMBL44 GENISTEIN IC50 = 10924.0 nM 4.96
CHEMBL18701 RO-201724 IC50 = 11316.0 nM 4.95
CHEMBL10 SB-203580 IC50 = 11590.0 nM 4.94
CHEMBL1909069 — IC50 = 22409.0 nM 4.65
CHEMBL193 NIFEDIPINE IC50 = 44158.0 nM 4.36
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL1201237 LEVOBUNOLOL Ki - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 Ki - — -
CHEMBL1373 MODAFINIL IC50 - — -
CHEMBL503 LOVASTATIN IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL878 METOLAZONE IC50 - — -
CHEMBL878 METOLAZONE Ki - — -
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL80 NALOXONE Ki - — -
CHEMBL1221512 — Ki - — -
CHEMBL1221512 — IC50 - — -
CHEMBL64391 ITRACONAZOLE Ki - — -
CHEMBL80 NALOXONE IC50 - — -
CHEMBL1373 MODAFINIL Ki - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL1201139 MEGESTROL ACETATE Ki - — -
CHEMBL547 ISOTRETINOIN IC50 - — -
CHEMBL547 ISOTRETINOIN Ki - — -
CHEMBL191 LOSARTAN IC50 - — -
CHEMBL191 LOSARTAN Ki - — -
CHEMBL86 METOCLOPRAMIDE IC50 - — -
CHEMBL86 METOCLOPRAMIDE Ki - — -
CHEMBL6437 MIANSERIN IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL86304 MOCLOBEMIDE Ki - — -
CHEMBL1618305 NALOXONAZINE IC50 - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL741 LAMOTRIGINE IC50 - — -