Assay Detail
Binding
CHEMBL1909206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr))
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Insect cells |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.31 | 7.10 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 7.10 |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | — | 2 | 6.53 |
| CHEMBL1476898 | CADMIUM ACETATE | — | 2 | 6.08 |
| CHEMBL1201469 | GRAMICIDIN | 4.0 | 2 | 5.96 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 5.90 |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | 5.72 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.65 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 5.61 |
| CHEMBL86754 | IODOQUINOL | 2.0 | 2 | 5.61 |
| CHEMBL1386 | TRANSPLATIN | 3.0 | 2 | 5.57 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | 5.54 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 5.50 |
| CHEMBL1009 | LEVODOPA | 4.0 | 2 | 5.43 |
| CHEMBL24944 | TRIBROMSALAN | 4.0 | 2 | 5.30 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 2 | 5.26 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 5.19 |
| CHEMBL1200748 | CARBIDOPA | 4.0 | 2 | 5.17 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 5.09 |
| CHEMBL1630578 | TIRILAZAD | 3.0 | 2 | 4.80 |
| CHEMBL141343 | — | — | 2 | 4.77 |
| CHEMBL1201631 | INSULIN HUMAN | 4.0 | 2 | 4.74 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 4.70 |
| CHEMBL195437 | 4-OCTYLPHENOL | — | 2 | 4.66 |
| CHEMBL11359 | CISPLATIN | 4.0 | 2 | 4.64 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 2 | 4.50 |
| CHEMBL40583 | 3-METHYLCHOLANTHRENE | — | 2 | 4.26 |
| CHEMBL584 | NELFINAVIR | 4.0 | 2 | 4.10 |
| CHEMBL515914 | AZARIBINE | 4.0 | 2 | - |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | - |
| CHEMBL720 | BENZYL ALCOHOL | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | = | 293.8 | nM | 6.53 |
| CHEMBL1476898 | CADMIUM ACETATE | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL1201469 | GRAMICIDIN | IC50 | = | 1094.0 | nM | 5.96 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 1249.0 | nM | 5.90 |
| CHEMBL1200558 | BACITRACIN | IC50 | = | 1923.0 | nM | 5.72 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 2255.0 | nM | 5.65 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 2461.0 | nM | 5.61 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 2432.5 | nM | 5.61 |
| CHEMBL1386 | TRANSPLATIN | IC50 | = | 2721.0 | nM | 5.57 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 2887.0 | nM | 5.54 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 3182.0 | nM | 5.50 |
| CHEMBL1009 | LEVODOPA | IC50 | = | 3729.0 | nM | 5.43 |
| CHEMBL24944 | TRIBROMSALAN | IC50 | = | 5015.0 | nM | 5.30 |
| CHEMBL926 | DOBUTAMINE | IC50 | = | 5519.0 | nM | 5.26 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 6499.0 | nM | 5.19 |
| CHEMBL1200748 | CARBIDOPA | IC50 | = | 6795.0 | nM | 5.17 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 8033.0 | nM | 5.09 |
| CHEMBL1630578 | TIRILAZAD | IC50 | = | 15786.0 | nM | 4.80 |
| CHEMBL141343 | — | IC50 | = | 17137.0 | nM | 4.77 |
| CHEMBL1201631 | INSULIN HUMAN | IC50 | = | 18107.0 | nM | 4.74 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 19920.0 | nM | 4.70 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 22054.0 | nM | 4.66 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 22949.0 | nM | 4.64 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 31913.0 | nM | 4.50 |
| CHEMBL40583 | 3-METHYLCHOLANTHRENE | IC50 | = | 55452.0 | nM | 4.26 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 79166.0 | nM | 4.10 |
| CHEMBL21731 | MAPROTILINE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL558 | MEXILETINE | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL21731 | MAPROTILINE | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | IC50 | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL534 | KETOTIFEN | Ki | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - | |
| CHEMBL91 | MICONAZOLE | Ki | - | — | - | |
| CHEMBL534 | KETOTIFEN | IC50 | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - |