CHEMBL4523582 Target Snapshot

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Replicase polyprotein 1ab shows approved-linked disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P0DTD1. Start with COVID-19, then reuse UniProt P0DTD1 as the stable protein anchor across project notes and exports.

Review focus

Review-ready target frame

Start with COVID-19, then reuse UniProt P0DTD1 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs

Open source guide

Disease program

COVID-19

Replicase polyprotein 1ab shows approved-linked disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with COVID-19 because it currently carries approved-linked support. Linked drugs include GALIDESIVIR, REMDESIVIR, RO-0622. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy

Approved-linked Open Targets-ready proxy 3 linked drugs

Open disease block

Protein anchor

Replicase polyprotein 1ab

Review this target as Replicase polyprotein 1ab, mapped to UniProt P0DTD1. Sequence length is 7096 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P0DTD1 Protein 7096 aa

Open protein block

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Replicase polyprotein 1ab as ChEMBL target CHEMBL4523582, mapped to UniProt P0DTD1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Replicase polyprotein 1ab

SINGLE PROTEIN · Severe acute respiratory syndrome coronavirus 2

As of 2026-09-13

ChEMBL target ID

CHEMBL4523582

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P0DTD1

Replicase polyprotein 1ab

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Start here when your first question is whether Replicase polyprotein 1ab is the right protein anchor across sources, using UniProt P0DTD1 as the stable mapping.

Jump to Protein Context

Need disease fit before discussing compounds?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why COVID-19 is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

Jump to Disease Context

Need a meeting-ready explanation of why this target matters?

Evidence Card

Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card

Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Name	Replicase polyprotein 1ab
Target Type	SINGLE PROTEIN
Organism	Severe acute respiratory syndrome coronavirus 2
UniProt	P0DTD1

ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label	Replicase polyprotein 1ab
UniProt Accession	P0DTD1
Component Type	Protein
Sequence Length	7096 aa

Replicase polyprotein 1ab

Source · UniProt accession via ChEMBL component mapping Freshness · Sep 13, 2026, 12:15 PM KST As of · Sep 13, 2026

UniProt Context ↗

Review Cue

How to read this target

Review this target as Replicase polyprotein 1ab, mapped to UniProt P0DTD1. Sequence length is 7096 aa.

Mapped IDP0DTD1

Review nameReplicase polyprotein 1ab

OrganismSevere acute respiratory syndrome coronavirus 2

Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Replicase polyprotein 1ab shows approved-linked disease relevance led by COVID-19. 5 more disease programs remain visible in the same review block.

Approved-linked Approved

COVID-19

3 linked drugs · 3 direct · 3 efficacy

Linked drugGALIDESIVIR

Linked drugREMDESIVIR

Linked drugRO-0622

Approved-linked Approved

coronavirus infectious disease