Compound Detail

CHEMBL1382627

SULFADIAZINE, SILVER

💊 Approved Drug

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💊 Approved Drug

Nc1ccc(S(=O)(=O)[N-]c2ncccn2)cc1.[Ag+]

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1382627
Name	SULFADIAZINE, SILVER
Phase	Approved
Structure Type	MOL
InChI Key	UEJSSZHHYBHCEL-UHFFFAOYSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL439
Active Moiety	CHEMBL439

Known Names

Altreet-ag Dermazin Flamazine Flammacerium Sildaflo Silvadene Silvazine Silver sulfadiazine Silver sulphadiazine Ssd af Sulfadiazine silver Sulfadiazine silver salt +3 more

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

250.3

MW (Da)

0.86

ALogP

HBA

HBD

98.0

PSA (Å²)

0.79

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1973
Availability	Prescription
Chirality	Achiral

Routes of Administration

Topical

USAN Stem	sulfa-
USAN Year	1975

Extended Properties

Molecular Formula	C10H9AgN4O2S
MW	357.14
Aromatic Rings	2
Heavy Atoms	17
NP-Likeness	-1.65

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Bacterial dihydropteroate synthase inhibitor	INHIBITOR	Dihydropteroate synthase	✓	✓

Indications

Burns Infections Osteomyelitis

ATC Classification

D06BA01

silver sulfadiazine

Level 1: DERMATOLOGICALS

Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE

D06BA51

silver sulfadiazine, combinations

Level 1: DERMATOLOGICALS

Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE

Activity Summary

IC50 1 meas. best 6.12

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Replicase polyprotein 1ab CHEMBL4523582	IC50	6.12	6.12	750.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Replicase polyprotein 1ab	IC50	=	750.0	nM	6.12	SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response ...	-

Literature References

PubMed	DOI	Target Context	# Activities
22194678	10.1371/journal.pcbi.1002310	Hepatotoxicity	14
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	4
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
26703794	10.1016/j.ejmech.2015.11.032	Acinetobacter baumannii	1
-	10.21203/rs.3.rs-23951/v1	SARS-CoV-2	1
-	10.1101/2020.04.21.054387	SARS-CoV-2	1

Data from ChEMBL 36 via Core Engine