Assay Detail
Binding
CHEMBL5098527
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Inhibition of Dengue Virus 4 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.20 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | 4.0 | 1 | 6.89 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 6.19 |
| CHEMBL1458891 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1324 | TOLCAPONE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1458891 | — | IC50 | = | 2940.0 | nM | 5.53 |