Assay Detail
Binding
CHEMBL1291963
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Selectivity ratio of Ki for dopamine transporter in Sprague-Dawley rat brain to Ki for serotonin transporter in Sprague-Dawley rat brain
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Selectivity ratio | 29 | - | - |
| Ki | 2 | 6.06 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | 4.0 | 1 | 6.41 |
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | 4.0 | 1 | 5.70 |
| CHEMBL541124 | — | — | 1 | - |
| CHEMBL536264 | — | — | 1 | - |
| CHEMBL536952 | — | — | 1 | - |
| CHEMBL1290622 | — | — | 1 | - |
| CHEMBL1290741 | — | — | 1 | - |
| CHEMBL1288490 | — | — | 1 | - |
| CHEMBL1290742 | — | — | 1 | - |
| CHEMBL1289072 | — | — | 1 | - |
| CHEMBL1289073 | — | — | 1 | - |
| CHEMBL1289190 | — | — | 1 | - |
| CHEMBL1289191 | — | — | 1 | - |
| CHEMBL1289302 | — | — | 1 | - |
| CHEMBL1289303 | — | — | 1 | - |
| CHEMBL1289420 | — | — | 1 | - |
| CHEMBL1289421 | — | — | 1 | - |
| CHEMBL1289533 | — | — | 1 | - |
| CHEMBL1289534 | — | — | 1 | - |
| CHEMBL1289642 | — | — | 1 | - |
| CHEMBL1289643 | — | — | 1 | - |
| CHEMBL1289747 | — | — | 1 | - |
| CHEMBL1289748 | — | — | 1 | - |
| CHEMBL1289854 | — | — | 1 | - |
| CHEMBL1289855 | — | — | 1 | - |
| CHEMBL1289972 | — | — | 1 | - |
| CHEMBL1289973 | — | — | 1 | - |
| CHEMBL1290067 | — | — | 1 | - |
| CHEMBL1290068 | — | — | 1 | - |
| CHEMBL1290174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL6067650 | PAROXETINE HYDROCHLORIDE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | Selectivity ratio | = | 43.0 | — | - |
| CHEMBL541124 | — | Selectivity ratio | = | 6.7 | — | - |
| CHEMBL536264 | — | Selectivity ratio | = | 150.0 | — | - |
| CHEMBL536952 | — | Selectivity ratio | = | 160.0 | — | - |
| CHEMBL1290622 | — | Selectivity ratio | = | 159.0 | — | - |
| CHEMBL1290741 | — | Selectivity ratio | = | 980.0 | — | - |
| CHEMBL1288490 | — | Selectivity ratio | = | 1400.0 | — | - |
| CHEMBL1290742 | — | Selectivity ratio | = | 51.0 | — | - |
| CHEMBL1289072 | — | Selectivity ratio | = | 760.0 | — | - |
| CHEMBL1289073 | — | Selectivity ratio | = | 1600.0 | — | - |
| CHEMBL1289190 | — | Selectivity ratio | = | 1500.0 | — | - |
| CHEMBL1289191 | — | Selectivity ratio | = | 1200.0 | — | - |
| CHEMBL1289302 | — | Selectivity ratio | = | 370.0 | — | - |
| CHEMBL1289303 | — | Selectivity ratio | = | 260.0 | — | - |
| CHEMBL1289420 | — | Selectivity ratio | = | 520.0 | — | - |
| CHEMBL1289421 | — | Selectivity ratio | = | 47.0 | — | - |
| CHEMBL1289533 | — | Selectivity ratio | = | 100.0 | — | - |
| CHEMBL1289534 | — | Selectivity ratio | = | 110.0 | — | - |
| CHEMBL1289642 | — | Selectivity ratio | = | 227.0 | — | - |
| CHEMBL1289643 | — | Selectivity ratio | = | 96.0 | — | - |
| CHEMBL1289747 | — | Selectivity ratio | = | 48.0 | — | - |
| CHEMBL1289748 | — | Selectivity ratio | = | 560.0 | — | - |
| CHEMBL1289854 | — | Selectivity ratio | = | 4900.0 | — | - |
| CHEMBL1289855 | — | Selectivity ratio | = | 300.0 | — | - |
| CHEMBL1289972 | — | Selectivity ratio | = | 740.0 | — | - |
| CHEMBL1289973 | — | Selectivity ratio | = | 310.0 | — | - |
| CHEMBL1290067 | — | Selectivity ratio | = | 370.0 | — | - |
| CHEMBL1290068 | — | Selectivity ratio | = | 120.0 | — | - |
| CHEMBL1290174 | — | Selectivity ratio | = | 500.0 | — | - |