Compound Detail
CHEMBL1089
PHENELZINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1089 |
| Name | PHENELZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | RMUCZJUITONUFY-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
13
Targets
25
Activities
2
Assay Types
0
PK Parameters
20
Publications
2
Known Names
1
Indications
Molecular Properties
136.2
MW (Da)
0.69
ALogP
2
HBA
2
HBD
38.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1961 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Depressive Disorder
ATC Classification
N06AF03
phenelzine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOANALEPTICS
Activity Summary
IC50 13 meas. best 7.7
Ki 12 meas. best 7.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amine oxidase [copper-containing] 3 CHEMBL3437 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
| Amine oxidase [flavin-containing] A CHEMBL3358 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Amine oxidase [flavin-containing] B CHEMBL2993 | IC50 | 7.12 | 7.12 | 76.3 | 1 |
| Amine oxidase [flavin-containing] B CHEMBL2039 | Ki | 7.03 | 6.97 | 94.0 | 2 |
| Amine oxidase [flavin-containing] A CHEMBL1951 | IC50 | 6.84 | 6.73 | 146.0 | 2 |
| Amine oxidase [flavin-containing] B CHEMBL2039 | IC50 | 6.84 | 5.75 | 143.0 | 2 |
| Amine oxidase [flavin-containing] A CHEMBL1951 | Ki | 6.79 | 6.79 | 163.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.15 | 6.15 | 708.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Cytochrome P450 2C8 CHEMBL3721 | Ki | 5.92 | 5.09 | 1200.0 | 2 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
| Lysine-specific histone demethylase 1A CHEMBL6136 | Ki | 5.25 | 5.0314 | 5600.0 | 7 |
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine