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Target Snapshot

CHEMBL3437 Target Snapshot

Amine oxidase [copper-containing] 3 · SINGLE PROTEIN · Homo sapiens

1,234Compounds
65Assays
1Approved Drugs
1,755.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q16853. Use UniProt Q16853 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q16853 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amine oxidase [copper-containing] 3 as ChEMBL target CHEMBL3437, mapped to UniProt Q16853. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amine oxidase [copper-containing] 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3437
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q16853
Amine oxidase [copper-containing] 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Amine oxidase [copper-containing] 3 is the right protein anchor across sources, using UniProt Q16853 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmine oxidase [copper-containing] 3
UniProt AccessionQ16853
Component TypeProtein
Sequence Length763 aa

Amine oxidase [copper-containing] 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Amine oxidase [copper-containing] 3, mapped to UniProt Q16853. Sequence length is 763 aa.

Mapped IDQ16853
Review nameAmine oxidase [copper-containing] 3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC501,751.0
KI2.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5949667 10.4 IC50 0.04 Preclinical
CHEMBL5930465 10.05 IC50 0.09 Preclinical
CHEMBL6030001 9.96 IC50 0.11 Preclinical
CHEMBL6053891 9.85 IC50 0.14 Preclinical
CHEMBL5774203 9.7 IC50 0.2 Preclinical
CHEMBL5884221 9.7 IC50 0.2 Preclinical
CHEMBL5909558 9.7 IC50 0.2 Preclinical
CHEMBL5977694 9.7 IC50 0.2 Preclinical
CHEMBL6001768 9.7 IC50 0.2 Preclinical
CHEMBL6016570 9.7 IC50 0.2 Preclinical
Distribution

pChEMBL Value Distribution

53
5.0
41
5.5
209
6.0
248
6.5
86
7.0
100
7.5
58
8.0
68
8.5
91
9.0
34
9.5
pChEMBL
Approved Drugs

Approved Drugs

PHENELZINE
CHEMBL1089
Approved 1961
Assay Landscape

Assay Landscape

65
Total Assays
823
Tested Compounds
3
Assay Types
Binding — 60 assays, 823 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 38 460 7.0
cell-based format 11 162 6.4
assay format 7 193 7.7
cell-free format 3 7 5.7
tissue-based format 1 1 4.7
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0
single protein format 2 0
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine