Assay Detail
Binding
CHEMBL733229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to inhibit Monoamine oxidase A activity in rat whole brain in vitro
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.97 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089 | PHENELZINE | 4.0 | 1 | 7.52 |
| CHEMBL89976 | — | — | 1 | 6.44 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.29 |
| CHEMBL328551 | — | — | 1 | 5.93 |
| CHEMBL90721 | — | — | 1 | 5.81 |
| CHEMBL90653 | — | — | 1 | 5.73 |
| CHEMBL328113 | — | — | 1 | 5.10 |
| CHEMBL328446 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089 | PHENELZINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL89976 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL972 | SELEGILINE | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL328551 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL90721 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL90653 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL328113 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL328446 | — | IC50 | = | 11300.0 | nM | 4.95 |