Assay Detail
Binding
CHEMBL729460
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In vitro ability to inhibit Monoamine oxidase B activity in rat whole brain in vitro
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.36 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.56 |
| CHEMBL1089 | PHENELZINE | 4.0 | 1 | 7.12 |
| CHEMBL90144 | — | — | 1 | 7.12 |
| CHEMBL90721 | — | — | 1 | 6.92 |
| CHEMBL328446 | — | — | 1 | 6.00 |
| CHEMBL89976 | — | — | 1 | 5.55 |
| CHEMBL90653 | — | — | 1 | 5.50 |
| CHEMBL328551 | — | — | 1 | 5.45 |
| CHEMBL328113 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 2.76 | nM | 8.56 |
| CHEMBL1089 | PHENELZINE | IC50 | = | 76.3 | nM | 7.12 |
| CHEMBL90144 | — | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL90721 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL328446 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL89976 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL90653 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL328551 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL328113 | — | IC50 | = | 10200.0 | nM | 4.99 |