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Assay Detail

CHEMBL3365093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins by HPLC
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Röhrig UF, Majjigapu SR, Chambon M, Bron S, Pilotte L, Colau D, Van den Eynde BJ, Turcatti G, Vogel P, Zoete V, Michielin O.
Eur J Med Chem (2014) 84 : 284 -301
PubMed 25036789 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 5.07 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3318327 1 6.15
CHEMBL1562612 1 6.05
CHEMBL3318328 1 6.00
CHEMBL3318329 1 5.75
CHEMBL1221 SULCONAZOLE 4.0 1 5.19
CHEMBL91 MICONAZOLE 4.0 1 5.17
CHEMBL3318330 1 5.16
CHEMBL808 ECONAZOLE 4.0 1 5.09
CHEMBL1201196 SERTACONAZOLE 4.0 1 5.08
CHEMBL489102 1 4.96
CHEMBL3318331 1 4.89
CHEMBL1089 PHENELZINE 4.0 1 4.85
CHEMBL3318332 1 4.82
CHEMBL277535 BIFONAZOLE 3.0 1 4.64
CHEMBL356918 ENILCONAZOLE 2.0 1 4.64
CHEMBL1571863 ISOCONAZOLE 2.0 1 4.64
CHEMBL1262 OXICONAZOLE 4.0 1 4.55
CHEMBL157101 KETOCONAZOLE 4.0 1 4.50
CHEMBL3318333 1 4.27
CHEMBL3318339 1 -
CHEMBL3318340 1 -
CHEMBL3318341 1 -
CHEMBL3318342 1 -
CHEMBL3318343 1 -
CHEMBL3318344 1 -
CHEMBL212845 1 -
CHEMBL3318345 1 -
CHEMBL3318346 1 -
CHEMBL3318347 1 -
CHEMBL3318348 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3318327 IC50 = 710.0 nM 6.15
CHEMBL1562612 IC50 = 890.0 nM 6.05
CHEMBL3318328 IC50 = 1000.0 nM 6.00
CHEMBL3318329 IC50 = 1800.0 nM 5.75
CHEMBL1221 SULCONAZOLE IC50 = 6400.0 nM 5.19
CHEMBL91 MICONAZOLE IC50 = 6700.0 nM 5.17
CHEMBL3318330 IC50 = 7000.0 nM 5.16
CHEMBL808 ECONAZOLE IC50 = 8100.0 nM 5.09
CHEMBL1201196 SERTACONAZOLE IC50 = 8400.0 nM 5.08
CHEMBL489102 IC50 = 11000.0 nM 4.96
CHEMBL3318331 IC50 = 13000.0 nM 4.89
CHEMBL1089 PHENELZINE IC50 = 14000.0 nM 4.85
CHEMBL3318332 IC50 = 15000.0 nM 4.82
CHEMBL1571863 ISOCONAZOLE IC50 = 23000.0 nM 4.64
CHEMBL356918 ENILCONAZOLE IC50 = 23000.0 nM 4.64
CHEMBL277535 BIFONAZOLE IC50 = 23000.0 nM 4.64
CHEMBL1262 OXICONAZOLE IC50 = 28000.0 nM 4.55
CHEMBL157101 KETOCONAZOLE IC50 = 32000.0 nM 4.50
CHEMBL3318333 IC50 = 54000.0 nM 4.27
CHEMBL1574 PHENTERMINE IC50 - -
CHEMBL1726 NISOLDIPINE IC50 - -
CHEMBL81 RALOXIFENE IC50 - -
CHEMBL193 NIFEDIPINE IC50 - -
CHEMBL3318334 IC50 - -
CHEMBL3318335 IC50 - -
CHEMBL2396945 IC50 - -
CHEMBL3318336 IC50 - -
CHEMBL3318337 IC50 - -
CHEMBL1706632 IC50 - -
CHEMBL3318338 IC50 - -
CHEMBL1591365 LIRANAFTATE IC50 - -
CHEMBL3317460 IC50 - -
CHEMBL3318355 IC50 - -
CHEMBL3318354 IC50 - -
CHEMBL3318353 IC50 - -
CHEMBL3318352 IC50 - -
CHEMBL3318351 IC50 - -
CHEMBL3318350 IC50 - -
CHEMBL3318349 IC50 - -
CHEMBL3318348 IC50 - -
CHEMBL3318347 IC50 - -
CHEMBL3318346 IC50 - -
CHEMBL3318345 IC50 - -
CHEMBL212845 IC50 - -
CHEMBL3318344 IC50 - -
CHEMBL3318343 IC50 - -
CHEMBL3318342 IC50 - -
CHEMBL3318341 IC50 - -
CHEMBL3318340 IC50 - -
CHEMBL3318339 IC50 - -