Compound Detail
CHEMBL277535
BIFONAZOLE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL277535 |
| Name | BIFONAZOLE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | OCAPBUJLXMYKEJ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
15
Targets
21
Activities
3
Assay Types
0
PK Parameters
20
Publications
7
Known Names
2
Indications
2
Mechanisms
Molecular Properties
310.4
MW (Da)
5.19
ALogP
2
HBA
0
HBD
17.8
PSA (Ų)
0.51
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Lanosterol 14-alpha demethylase inhibitor | INHIBITOR | Lanosterol 14-alpha demethylase | ✓ | ✓ |
| HMG-CoA reductase inhibitor | INHIBITOR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ✓ | ✓ |
Indications
Onychomycosis Tinea Pedis
ATC Classification
D01AC10
bifonazole
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
D01AC60
bifonazole, combinations
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
Activity Summary
IC50 19 meas. best 8.52
EC50 1 meas. best 4.75
Ki 1 meas. best 7.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 8.52 | 7.605 | 3.0 | 2 |
| Steroid 17-alpha-hydroxylase/17,20 lyase CHEMBL3522 | Ki | 7.25 | 7.25 | 56.5 | 1 |
| Lanosterol 14-alpha demethylase CHEMBL3849 | IC50 | 6.47 | 6.47 | 342.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase CHEMBL3522 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.5 | 5.5 | 3180.0 | 1 |
| Leishmania donovani CHEMBL367 | IC50 | 5.26 | 5.26 | 5480.0 | 1 |
| Cysteine protease ATG4B CHEMBL1741221 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
| Leishmania chagasi CHEMBL612790 | IC50 | 5.05 | 5.05 | 8970.0 | 1 |
| Phospholipase A2 CHEMBL4426 | IC50 | 5.05 | 5.05 | 8890.0 | 1 |
| Calpain-2 catalytic subunit CHEMBL4143 | IC50 | 4.83 | 4.83 | 14706.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.77 | 4.63 | 17000.0 | 4 |
| Unchecked CHEMBL612545 | EC50 | 4.75 | 4.75 | 17800.0 | 1 |
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | IC50 | 4.64 | 4.64 | 23000.0 | 1 |
| Bile salt export pump CHEMBL6020 | IC50 | 4.57 | 4.57 | 27100.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 4.57 | 4.57 | 26800.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.41 | 4.41 | 39300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine