Assay Detail
Functional
CHEMBL3392938
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DNDI: Cytotoxicity in Vitro, 72 hour, in rat skeletal myoblast cells
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 4.75 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 6.39 |
| CHEMBL3039774 | — | — | 1 | 6.11 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 5.98 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.96 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.64 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.60 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.52 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 5.49 |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 5.32 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 5.27 |
| CHEMBL3392933 | — | — | 1 | 5.26 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 5.09 |
| CHEMBL585 | TRIAMTERENE | 4.0 | 1 | 5.07 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.05 |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 5.03 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 5.00 |
| CHEMBL487366 | — | — | 1 | 4.99 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 4.96 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 4.94 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 4.92 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.91 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 4.91 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 1 | 4.88 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 4.86 |
| CHEMBL436921 | — | — | 1 | 4.84 |
| CHEMBL1169388 | — | — | 1 | 4.83 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.81 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 4.81 |
| CHEMBL437765 | RIFAMYCIN | 4.0 | 1 | 4.80 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3039774 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL3392933 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL809 | SERTRALINE | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL585 | TRIAMTERENE | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL487366 | — | IC50 | = | 10270.0 | nM | 4.99 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 10990.0 | nM | 4.96 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 11540.0 | nM | 4.94 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 12310.0 | nM | 4.91 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL490 | PAROXETINE | IC50 | = | 13840.0 | nM | 4.86 |
| CHEMBL436921 | — | IC50 | = | 14490.0 | nM | 4.84 |
| CHEMBL1169388 | — | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 15440.0 | nM | 4.81 |
| CHEMBL437765 | RIFAMYCIN | IC50 | = | 15680.0 | nM | 4.80 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 16160.0 | nM | 4.79 |
| CHEMBL296480 | — | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL570 | TRIFLUPROMAZINE | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 18920.0 | nM | 4.72 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 19470.0 | nM | 4.71 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 19790.0 | nM | 4.70 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 20620.0 | nM | 4.69 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 20520.0 | nM | 4.69 |
| CHEMBL3392936 | — | IC50 | = | 23490.0 | nM | 4.63 |
| CHEMBL826 | ENOXACIN | IC50 | = | 25010.0 | nM | 4.60 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 27870.0 | nM | 4.55 |
| CHEMBL564 | PROMAZINE | IC50 | = | 30060.0 | nM | 4.52 |
| CHEMBL1479 | DANAZOL | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 32310.0 | nM | 4.49 |
| CHEMBL163 | RITONAVIR | IC50 | = | 37730.0 | nM | 4.42 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 38640.0 | nM | 4.41 |
| CHEMBL277535 | BIFONAZOLE | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 42180.0 | nM | 4.38 |
| CHEMBL1237057 | — | IC50 | = | 42240.0 | nM | 4.37 |
| CHEMBL251689 | — | IC50 | = | 43180.0 | nM | 4.37 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 43350.0 | nM | 4.36 |