Assay Detail
Functional
CHEMBL3392942
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DNDI: Leish (axenic) in Vitro, 72 hour
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 4.97 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 6.96 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.82 |
| CHEMBL487366 | — | — | 1 | 6.47 |
| CHEMBL3039774 | — | — | 1 | 6.46 |
| CHEMBL437765 | RIFAMYCIN | 4.0 | 1 | 5.82 |
| CHEMBL3392927 | — | — | 1 | 5.82 |
| CHEMBL183041 | — | — | 1 | 5.79 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 5.79 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 5.67 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.65 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.62 |
| CHEMBL3392934 | — | — | 1 | 5.56 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 5.55 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.37 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 5.36 |
| CHEMBL83668 | TOLNAFTATE | 3.0 | 1 | 5.36 |
| CHEMBL277535 | BIFONAZOLE | 3.0 | 1 | 5.26 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 5.21 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | 5.06 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.05 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 5.03 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 5.02 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 5.01 |
| CHEMBL1479 | DANAZOL | 4.0 | 1 | 4.99 |
| CHEMBL2105542 | SATRANIDAZOLE | 2.0 | 1 | 4.98 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 4.93 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 4.87 |
| CHEMBL3392928 | — | — | 1 | 4.82 |
| CHEMBL3392933 | — | — | 1 | 4.75 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1366 | AURANOFIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL487366 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3039774 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL437765 | RIFAMYCIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3392927 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL183041 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3392934 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL83668 | TOLNAFTATE | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL277535 | BIFONAZOLE | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL163 | RITONAVIR | IC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1479 | DANAZOL | IC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL2105542 | SATRANIDAZOLE | IC50 | = | 10410.0 | nM | 4.98 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 13650.0 | nM | 4.87 |
| CHEMBL3392928 | — | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL3392933 | — | IC50 | = | 17910.0 | nM | 4.75 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 19770.0 | nM | 4.70 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 21760.0 | nM | 4.66 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 22410.0 | nM | 4.65 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 22390.0 | nM | 4.65 |
| CHEMBL822 | TERBINAFINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL436921 | — | IC50 | = | 24080.0 | nM | 4.62 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 38760.0 | nM | 4.41 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 38580.0 | nM | 4.41 |
| CHEMBL779 | TADALAFIL | IC50 | = | 40060.0 | nM | 4.40 |
| CHEMBL3392936 | — | IC50 | = | 42460.0 | nM | 4.37 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 45680.0 | nM | 4.34 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 46690.0 | nM | 4.33 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 48450.0 | nM | 4.32 |
| CHEMBL251689 | — | IC50 | = | 48580.0 | nM | 4.31 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 52930.0 | nM | 4.28 |
| CHEMBL3392929 | — | IC50 | = | 56430.0 | nM | 4.25 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 62020.0 | nM | 4.21 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 75680.0 | nM | 4.12 |
| CHEMBL296480 | — | IC50 | = | 77360.0 | nM | 4.11 |