Compound Detail
CHEMBL2105542
SATRANIDAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2105542 |
| Name | SATRANIDAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FNSHYEAUAUHIMB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
1
Indications
Molecular Properties
289.3
MW (Da)
-0.47
ALogP
7
HBA
0
HBD
118.7
PSA (Ų)
0.55
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Amebiasis
ATC Classification
P01AB08
satranidazole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
IC50 3 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leishmania donovani CHEMBL367 | IC50 | 4.98 | 4.98 | 10410.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 4.73 | 4.73 | 18700.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.72 | 4.72 | 19080.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leishmania donovani | IC50 | = | 10410.0 | nM | 4.98 | DNDI: Leish (axenic) in Vitro, 72 hour | - |
| Trypanosoma brucei rhodesiense | IC50 | = | 18700.0 | nM | 4.73 | DNDI: HAT in Vitro, 72 hour | - |
| Trypanosoma cruzi | IC50 | = | 19080.0 | nM | 4.72 | DNDI: Chagas in Vitro, 96 hour | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3392926 | NON-PROTEIN TARGET | 2 |
| - | 10.6019/CHEMBL3392926 | Leishmania donovani | 2 |
| - | 10.6019/CHEMBL3392926 | Trypanosoma cruzi | 1 |
| - | 10.6019/CHEMBL3392926 | Trypanosoma brucei rhodesiense | 1 |
Data from ChEMBL 36 via Core Engine