Assay Detail
Functional
CHEMBL3392937
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DNDI: Chagas in Vitro, 96 hour
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 5.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277535 | BIFONAZOLE | 3.0 | 1 | 8.52 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 8.40 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 8.22 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 7.40 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 7.40 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 7.19 |
| CHEMBL3392934 | — | — | 1 | 6.72 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 6.64 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.57 |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 5.64 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 5.60 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.60 |
| CHEMBL282121 | MEBEVERINE | 3.0 | 1 | 5.41 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 5.36 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 5.35 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.24 |
| CHEMBL3392933 | — | — | 1 | 5.21 |
| CHEMBL1479 | DANAZOL | 4.0 | 1 | 5.20 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 5.17 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 5.07 |
| CHEMBL3039774 | — | — | 1 | 5.05 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 5.02 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 5.00 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 4.99 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 4.99 |
| CHEMBL638 | VORICONAZOLE | 4.0 | 1 | 4.95 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 1 | 4.94 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 4.91 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277535 | BIFONAZOLE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3392934 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL282121 | MEBEVERINE | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL3392933 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL1479 | DANAZOL | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL809 | SERTRALINE | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL779 | TADALAFIL | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3039774 | — | IC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 9460.0 | nM | 5.02 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL638 | VORICONAZOLE | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 11450.0 | nM | 4.94 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 12980.0 | nM | 4.89 |
| CHEMBL490 | PAROXETINE | IC50 | = | 14360.0 | nM | 4.84 |
| CHEMBL570 | TRIFLUPROMAZINE | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL296480 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 17150.0 | nM | 4.77 |
| CHEMBL251689 | — | IC50 | = | 17850.0 | nM | 4.75 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 17940.0 | nM | 4.75 |
| CHEMBL1169388 | — | IC50 | = | 19140.0 | nM | 4.72 |
| CHEMBL2105542 | SATRANIDAZOLE | IC50 | = | 19080.0 | nM | 4.72 |
| CHEMBL83668 | TOLNAFTATE | IC50 | = | 19970.0 | nM | 4.70 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 20290.0 | nM | 4.69 |
| CHEMBL163 | RITONAVIR | IC50 | = | 20670.0 | nM | 4.68 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 21980.0 | nM | 4.66 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL585 | TRIAMTERENE | IC50 | = | 22740.0 | nM | 4.64 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 22890.0 | nM | 4.64 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 24870.0 | nM | 4.60 |
| CHEMBL3392929 | — | IC50 | = | 27510.0 | nM | 4.56 |
| CHEMBL183041 | — | IC50 | = | 28210.0 | nM | 4.55 |