Assay Detail
Functional
CHEMBL3392941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DNDI: HAT in Vitro, 72 hour
100
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 100 | 5.11 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.00 |
| CHEMBL1366 | AURANOFIN | 4.0 | 1 | 8.00 |
| CHEMBL244888 | NIFUROXAZIDE | 3.0 | 1 | 7.52 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | 6.30 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 6.28 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 6.28 |
| CHEMBL487366 | — | — | 1 | 6.12 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 6.11 |
| CHEMBL242580 | CICLOPIROX OLAMINE | 3.0 | 1 | 6.10 |
| CHEMBL437765 | RIFAMYCIN | 4.0 | 1 | 6.00 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 5.95 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 5.93 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 5.91 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 5.90 |
| CHEMBL570 | TRIFLUPROMAZINE | 4.0 | 1 | 5.85 |
| CHEMBL3392933 | — | — | 1 | 5.85 |
| CHEMBL3392934 | — | — | 1 | 5.84 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.78 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 5.73 |
| CHEMBL1169388 | — | — | 1 | 5.70 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 5.69 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.69 |
| CHEMBL564 | PROMAZINE | 4.0 | 1 | 5.67 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 5.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.42 |
| CHEMBL294951 | PIZOTYLINE | 2.0 | 1 | 5.40 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.37 |
| CHEMBL251689 | — | — | 1 | 5.32 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 5.31 |
| CHEMBL3392936 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1366 | AURANOFIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL244888 | NIFUROXAZIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL572 | NITROFURANTOIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL487366 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL809 | SERTRALINE | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL437765 | RIFAMYCIN | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL490 | PAROXETINE | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL570 | TRIFLUPROMAZINE | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3392933 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3392934 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1169388 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL564 | PROMAZINE | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL294951 | PIZOTYLINE | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL163 | RITONAVIR | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL251689 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL3392936 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 10810.0 | nM | 4.97 |
| CHEMBL296480 | — | IC50 | = | 12270.0 | nM | 4.91 |
| CHEMBL3392929 | — | IC50 | = | 12610.0 | nM | 4.90 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL3392935 | — | IC50 | = | 13830.0 | nM | 4.86 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL534 | KETOTIFEN | IC50 | = | 15190.0 | nM | 4.82 |
| CHEMBL3392927 | — | IC50 | = | 16740.0 | nM | 4.78 |
| CHEMBL3039774 | — | IC50 | = | 16780.0 | nM | 4.78 |
| CHEMBL1357558 | — | IC50 | = | 16570.0 | nM | 4.78 |
| CHEMBL3392928 | — | IC50 | = | 17140.0 | nM | 4.77 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 18450.0 | nM | 4.73 |
| CHEMBL2105542 | SATRANIDAZOLE | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 20610.0 | nM | 4.69 |