Compound Detail
CHEMBL822
TERBINAFINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL822 |
| Name | TERBINAFINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DOMXUEMWDBAQBQ-WEVVVXLNSA-N |
| Therapeutic | ✓ Yes |
27
Targets
57
Activities
2
Assay Types
4
PK Parameters
20
Publications
9
Known Names
8
Indications
1
Mechanisms
Molecular Properties
291.4
MW (Da)
4.88
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1992 |
| Availability | OTC |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Squalene monooxygenase inhibitor | INHIBITOR | Squalene monooxygenase | ✓ | ✓ |
Indications
Onychomycosis Onychomycosis Tinea Tinea Pedis Colitis, Ulcerative Crohn Disease Hepatitis B, Chronic Mycoses
ATC Classification
D01AE15
terbinafine
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
D01BA02
terbinafine
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
Activity Summary
IC50 51 meas. best 8.0
Ki 6 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trichophyton quinckeanum CHEMBL612334 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.66 | 6.775 | 21.8 | 2 |
| Trichophyton rubrum CHEMBL612649 | IC50 | 7.52 | 6.6867 | 30.0 | 3 |
| Squalene monooxygenase CHEMBL3592 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.45 | 6.65 | 35.4 | 2 |
| Trichophyton mentagrophytes CHEMBL613162 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Microsporum canis CHEMBL612335 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 6.63 | 6.63 | 235.4 | 1 |
| Aspergillus flavus CHEMBL614955 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Candida parapsilosis CHEMBL612868 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Cryptococcus neoformans CHEMBL365 | IC50 | 6.4 | 6.35 | 400.0 | 2 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 6.25 | 6.25 | 560.2 | 1 |
| Aspergillus niger CHEMBL358 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| Aspergillus fumigatus CHEMBL363 | IC50 | 6.0 | 5.98 | 1000.0 | 2 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 5.67 | 5.67 | 2138.6 | 1 |
| Candida albicans CHEMBL366 | IC50 | 5.58 | 5.0988 | 2600.0 | 8 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.39 | 5.39 | 4095.4 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 5.38 | 5.38 | 4129.5 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 5.24 | 5.24 | 5702.9 | 1 |
| Squalene monooxygenase CHEMBL3592 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Kluyveromyces marxianus CHEMBL612842 | IC50 | 5.2 | 5.2 | 6330.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.11 | 5.11 | 7720.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.77 | 4.5044 | 17100.0 | 9 |
| Leishmania donovani CHEMBL367 | IC50 | 4.64 | 4.4 | 23000.0 | 2 |
| Nakaseomyces glabratus CHEMBL612647 | IC50 | 4.51 | 4.51 | 30660.0 | 1 |
| Candida tropicalis CHEMBL612870 | IC50 | 4.34 | 4.34 | 45400.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.33 | 4.33 | 46970.0 | 1 |
| Pichia kudriavzevii CHEMBL612841 | IC50 | 4.19 | 4.19 | 64000.0 | 1 |
| J774 CHEMBL614123 | IC50 | 4.06 | 4.06 | 88000.0 | 2 |
| Squalene monooxygenase CHEMBL4241 | IC50 | 4.03 | 4.03 | 93000.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 4.02 | 4.02 | 95150.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 205.87 | nM | Cavia porcellus |
| F | 49.0 | % | Homo sapiens |
| T1/2 | 6.6 | hr | Cavia porcellus |
| Tmax | 0.7 | hr | Cavia porcellus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine