Assay Detail
Functional
CHEMBL1279754
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Antifungal activity against Cryptococcus neoformans ATCC 66031 after 72 hrs by CLSI method
26
Total Activities
11
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cryptococcus neoformans |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.36 | 7.70 |
| MIC | 8 | - | - |
| MFC | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 3 | 7.70 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 3 | 7.10 |
| CHEMBL1630575 | CASPOFUNGIN | 4.0 | 3 | 7.00 |
| CHEMBL822 | TERBINAFINE | 4.0 | 3 | 6.40 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 3 | 6.16 |
| CHEMBL454322 | 6-NONADECYNOIC ACID | — | 1 | 5.96 |
| CHEMBL1269413 | — | — | 3 | 5.92 |
| CHEMBL1275976 | — | — | 2 | 5.92 |
| CHEMBL454321 | 6-OCTADECYNOIC ACID | — | 1 | 5.85 |
| CHEMBL1276010 | UNDECYLENIC ACID | -1.0 | 3 | 5.57 |
| CHEMBL482804 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1630575 | CASPOFUNGIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL822 | TERBINAFINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL454322 | 6-NONADECYNOIC ACID | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1269413 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1275976 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL454321 | 6-OCTADECYNOIC ACID | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1276010 | UNDECYLENIC ACID | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1269413 | — | MIC | = | 49500.0 | nM | - |
| CHEMBL1269413 | — | MFC | = | 99.1 | uM | - |
| CHEMBL482804 | — | IC50 | > | 178600.0 | nM | - |
| CHEMBL1275976 | — | MIC | = | 187700.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | MIC | = | 340.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | MFC | = | 0.34 | uM | - |
| CHEMBL106 | FLUCONAZOLE | MIC | = | 5100.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | MFC | = | 20.4 | uM | - |
| CHEMBL157101 | KETOCONAZOLE | MIC | = | 150.0 | nM | - |
| CHEMBL157101 | KETOCONAZOLE | MFC | = | 0.59 | uM | - |
| CHEMBL1630575 | CASPOFUNGIN | MIC | = | 500.0 | nM | - |
| CHEMBL1630575 | CASPOFUNGIN | MFC | = | 1.0 | uM | - |
| CHEMBL1276010 | UNDECYLENIC ACID | MIC | = | 135700.0 | nM | - |
| CHEMBL1276010 | UNDECYLENIC ACID | MFC | = | 271.3 | uM | - |
| CHEMBL822 | TERBINAFINE | MIC | = | 4300.0 | nM | - |
| CHEMBL822 | TERBINAFINE | MFC | = | 8.6 | uM | - |