Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1279751

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Aspergillus flavus ATCC 204304 after 5 days by CLSI method
11
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Aspergillus flavus
Confidence 1 — Organism
Curated By Autocuration

Target

Aspergillus flavus (CHEMBL614955)
Type ORGANISM
Organism Aspergillus flavus

Publication

Potent in vitro antifungal activities of naturally occurring acetylenic acids.
Li XC, Jacob MR, Khan SI, Ashfaq MK, Babu KS, Agarwal AK, Elsohly HN, Manly SP, Clark AM.
Antimicrob Agents Chemother (2008) 52 : 2442 -2448
PubMed 18458131 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 5.96 6.52
MIC 4 - -
MFC 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL822 TERBINAFINE 4.0 3 6.52
CHEMBL267345 AMPHOTERICIN B 4.0 2 5.82
CHEMBL157101 KETOCONAZOLE 4.0 2 5.55
CHEMBL1269413 3 -
CHEMBL458328 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL822 TERBINAFINE IC50 = 300.0 nM 6.52
CHEMBL267345 AMPHOTERICIN B IC50 = 1500.0 nM 5.82
CHEMBL157101 KETOCONAZOLE IC50 = 2800.0 nM 5.55
CHEMBL1269413 IC50 = 105900.0 nM -
CHEMBL1269413 MIC = 198100.0 nM -
CHEMBL1269413 MFC = 198.1 uM -
CHEMBL458328 IC50 > 168900.0 nM -
CHEMBL267345 AMPHOTERICIN B MIC = 2700.0 nM -
CHEMBL157101 KETOCONAZOLE MIC = 4700.0 nM -
CHEMBL822 TERBINAFINE MIC = 2100.0 nM -
CHEMBL822 TERBINAFINE MFC = 8.6 uM -