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Target Snapshot

CHEMBL612842 Target Snapshot

Kluyveromyces marxianus · ORGANISM · Kluyveromyces marxianus

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680Compounds
124Assays
3Approved Drugs
4.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Kluyveromyces marxianus as ChEMBL target CHEMBL612842. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Kluyveromyces marxianus
ORGANISM · Kluyveromyces marxianus
As of 2026-09-14
ChEMBL target ID
CHEMBL612842
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKluyveromyces marxianus
Target TypeORGANISM
OrganismKluyveromyces marxianus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKluyveromyces marxianus
UniProt AccessionN/A

Kluyveromyces marxianus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Kluyveromyces marxianus.

Review nameKluyveromyces marxianus
OrganismKluyveromyces marxianus
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL91 7.52 IC50 30.0 Approved
CHEMBL175633 6.89 IC50 130.0 Clinical
CHEMBL64391 6.4 IC50 400.0 Approved
CHEMBL822 5.2 IC50 6330.0 Approved
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
1
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ITRACONAZOLE
CHEMBL64391
Approved 1992
Properties Compare Identifier
MICONAZOLE
CHEMBL91
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

127
Total Assays
4
Tested Compounds
1
Assay Types
Functional — 127 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 126 4 6.5
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine