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Compound Detail

CHEMBL175633

PRAMICONAZOLE
🧪 Phase II
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🧪 Phase II
CC(C)N1CCN(c2ccc(N3CCN(c4ccc(OC[C@H]5OC[C@](Cn6cncn6)(c6ccc(F)cc6F)O5)cc4)CC3)cc2)C1=O

Basic Information

ChEMBL ID CHEMBL175633
Name PRAMICONAZOLE
Phase Phase II
Structure Type MOL
InChI Key AEKNYBWUEYNWMJ-QWOOXDRHSA-N

Known Names

Pramiconazol Pramiconazole R-126638 R126638
8
Targets
10
Activities
1
Assay Types
3
PK Parameters
20
Publications
4
Known Names

Molecular Properties

659.7
MW (Da)
4.88
ALogP
9
HBA
0
HBD
88.4
PSA (Ų)
0.24
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -conazole
USAN Year 2006

Extended Properties

Molecular Formula C35H39F2N7O4
MW 659.74
Aromatic Rings 4
Heavy Atoms 48
NP-Likeness -0.89

Activity Summary

IC50 10 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Candida albicans
CHEMBL366
IC50 7.4 6.57 40.0 2
Kluyveromyces marxianus
CHEMBL612842
IC50 6.89 6.89 130.0 1
Trichophyton mentagrophytes
CHEMBL613162
IC50 6.82 6.82 150.0 1
Microsporum canis
CHEMBL612335
IC50 6.75 6.75 180.0 1
Trichophyton rubrum
CHEMBL612649
IC50 6.72 6.59 190.0 2
Nakaseomyces glabratus
CHEMBL612647
IC50 6.19 6.19 650.0 1
Pichia kudriavzevii
CHEMBL612841
IC50 6.06 6.06 870.0 1
Trichophyton quinckeanum
CHEMBL612334
IC50 5.87 5.87 1340.0 1

Pharmacokinetic Data

Parameter Value Units Species
Cmax 272.83 nM Cavia porcellus
T1/2 23.0 hr Cavia porcellus
Tmax 4.0 hr Cavia porcellus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15771461 10.1021/jm0494772 NON-PROTEIN TARGET 8
20805398 10.1128/aac.00730-10 Candida albicans 6
15771461 10.1021/jm0494772 Cavia porcellus 6
15771461 10.1021/jm0494772 Trichophyton tonsurans 4
- 10.6019/CHEMBL4651402 SARS-CoV-2 4
15771461 10.1021/jm0494772 Trichophyton rubrum 4
15771461 10.1021/jm0494772 Trichophyton benhamiae 4
15771461 10.1021/jm0494772 Aspergillus sp. 4
15771461 10.1021/jm0494772 Candida 4
15771461 10.1021/jm0494772 Epidermophyton floccosum 4
15771461 10.1021/jm0494772 Mus musculus 2
20805398 10.1128/aac.00730-10 Trichophyton rubrum 2
20805398 10.1128/aac.00730-10 Cavia porcellus 2
20805398 10.1128/aac.00730-10 MRC5 1
20805398 10.1128/aac.00730-10 Microsporum canis 1
20805398 10.1128/aac.00730-10 Trichophyton mentagrophytes 1
20805398 10.1128/aac.00730-10 Trichophyton quinckeanum 1
20805398 10.1128/aac.00730-10 Nakaseomyces glabratus 1
20805398 10.1128/aac.00730-10 Kluyveromyces marxianus 1
20805398 10.1128/aac.00730-10 Pichia kudriavzevii 1

Data from ChEMBL 36 via Core Engine