Assay Detail
Functional
CHEMBL1676505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antifungal activity against 5 x 10'6 CFU/ml Trichophyton mentagrophytes B70554 by resazurin based fluorimetry assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trichophyton mentagrophytes |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trichophyton mentagrophytes (CHEMBL613162) ↗| Type | ORGANISM |
| Organism | Trichophyton mentagrophytes |
Publication
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.72 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL822 | TERBINAFINE | 4.0 | 1 | 7.22 |
| CHEMBL175633 | PRAMICONAZOLE | 2.0 | 1 | 6.82 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 6.43 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL822 | TERBINAFINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL175633 | PRAMICONAZOLE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 400.0 | nM | 6.40 |