Assay Detail
Binding
CHEMBL1909111
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DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.05 | 7.67 |
| Ki | 871 | 6.26 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404849 | SULOCTIDIL | 4.0 | 2 | 7.88 |
| CHEMBL822 | TERBINAFINE | 4.0 | 2 | 7.66 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 2 | 7.52 |
| CHEMBL253376 | BROMHEXINE | 3.0 | 2 | 7.44 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 7.44 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 2 | 7.42 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | 7.23 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | 7.16 |
| CHEMBL633 | AMIODARONE | 4.0 | 2 | 7.14 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 7.01 |
| CHEMBL43064 | CINNARIZINE | 2.0 | 2 | 7.00 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 2 | 6.96 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 2 | 6.95 |
| CHEMBL990 | BUTENAFINE | 4.0 | 2 | 6.80 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 6.73 |
| CHEMBL1714574 | TERCONAZOLE | 4.0 | 2 | 6.71 |
| CHEMBL81 | RALOXIFENE | 4.0 | 2 | 6.62 |
| CHEMBL1123 | DICYCLOMINE | 4.0 | 2 | 6.54 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 6.43 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 6.42 |
| CHEMBL395110 | MEPAZINE | 4.0 | 2 | 6.41 |
| CHEMBL728 | PROCHLORPERAZINE | 4.0 | 2 | 6.38 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 6.35 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 6.28 |
| CHEMBL1198 | PRAMOXINE | 4.0 | 2 | 6.20 |
| CHEMBL1902981 | EPERISONE | 3.0 | 2 | 6.18 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 2 | 6.09 |
| CHEMBL621 | TRAZODONE | 4.0 | 2 | 6.08 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 2 | 6.07 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 2 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404849 | SULOCTIDIL | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL404849 | SULOCTIDIL | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL822 | TERBINAFINE | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL954 | ENCLOMIPHENE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL822 | TERBINAFINE | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL253376 | BROMHEXINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL30008 | FLUNARIZINE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL253376 | BROMHEXINE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL12089 | BERBERINE CHLORIDE | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL633 | AMIODARONE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL43064 | CINNARIZINE | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL1729 | CISAPRIDE | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL633 | AMIODARONE | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL990 | BUTENAFINE | Ki | = | 156.7 | nM | 6.80 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL43064 | CINNARIZINE | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL1729 | CISAPRIDE | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL1714574 | TERCONAZOLE | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL81 | RALOXIFENE | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL990 | BUTENAFINE | IC50 | = | 254.7 | nM | 6.59 |
| CHEMBL1123 | DICYCLOMINE | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL1714574 | TERCONAZOLE | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 372.0 | nM | 6.43 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL395110 | MEPAZINE | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL728 | PROCHLORPERAZINE | Ki | = | 416.0 | nM | 6.38 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL1123 | DICYCLOMINE | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL1909072 | PIPAMAZINE | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL1198 | PRAMOXINE | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL395110 | MEPAZINE | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL1902981 | EPERISONE | Ki | = | 655.0 | nM | 6.18 |
| CHEMBL728 | PROCHLORPERAZINE | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL1231 | OXYBUTYNIN | Ki | = | 820.3 | nM | 6.09 |