Squalene monooxygenase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q14534. Use UniProt Q14534 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14534 as the stable identity anchor, then attach disease evidence before program review.
Squalene monooxygenase
Review this target as Squalene monooxygenase, mapped to UniProt Q14534. Sequence length is 574 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Squalene monooxygenase as ChEMBL target CHEMBL3592, mapped to UniProt Q14534. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Squalene monooxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14534 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Squalene monooxygenase |
| UniProt Accession | Q14534 |
| Component Type | Protein |
| Sequence Length | 574 aa |
Squalene monooxygenase
Review this target as Squalene monooxygenase, mapped to UniProt Q14534. Sequence length is 574 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL15929 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL27885 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL107546 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL108692 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL822 | 7.52 | Ki | 30.0 | Approved |
| CHEMBL281025 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL324433 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL107568 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL107608 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL326008 | 7.16 | IC50 | 70.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 9 | 5.7 |
| assay format | 8 | 15 | 5.8 |
| cell-based format | 2 | 1 | 7.2 |
| microsome format | 2 | 2 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 20 | 6.5 |
| tissue-based format | 1 | 26 | 6.5 |