Compound Detail
CHEMBL107568
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Basic Information
| ChEMBL ID | CHEMBL107568 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QOHZDEJDJNDBJB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
447.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Squalene monooxygenase CHEMBL3592 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 6.92 | 6.92 | 120.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.54 | 6.54 | 290.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Squalene monooxygenase | IC50 | = | 70.0 | nM | 7.16 | In vitro inhibitory activity against pig liver microsomal squalene epoxidase | 7650673 |
| HepG2 | IC50 | = | 120.0 | nM | 6.92 | In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture f... | 7650673 |
| Unchecked | IC50 | = | 290.0 | nM | 6.54 | In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture f... | 7650673 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7650673 | 10.1021/jm00017a004 | Unchecked | 2 |
| 7650673 | 10.1021/jm00017a004 | Squalene monooxygenase | 1 |
| 7650673 | 10.1021/jm00017a004 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine