Assay Detail
Functional
CHEMBL695550
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In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]mevalonate.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.12 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15929 | — | — | 1 | 7.22 |
| CHEMBL107546 | — | — | 1 | 7.10 |
| CHEMBL108692 | — | — | 1 | 6.92 |
| CHEMBL323953 | — | — | 1 | 6.85 |
| CHEMBL107568 | — | — | 1 | 6.54 |
| CHEMBL326241 | — | — | 1 | 6.30 |
| CHEMBL322059 | — | — | 1 | 6.11 |
| CHEMBL108867 | — | — | 1 | 6.00 |
| CHEMBL107608 | — | — | 1 | 5.88 |
| CHEMBL326008 | — | — | 1 | 5.83 |
| CHEMBL111126 | — | — | 1 | 5.30 |
| CHEMBL110608 | — | — | 1 | 5.30 |
| CHEMBL324433 | — | — | 1 | 5.30 |
| CHEMBL107885 | — | — | 1 | 5.00 |
| CHEMBL321207 | — | — | 1 | - |
| CHEMBL108144 | — | — | 1 | - |
| CHEMBL111114 | — | — | 1 | - |
| CHEMBL109348 | — | — | 1 | - |
| CHEMBL109936 | — | — | 1 | - |
| CHEMBL107838 | — | — | 1 | - |
| CHEMBL326204 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15929 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107546 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL108692 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL323953 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL107568 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL326241 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL322059 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL108867 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL107608 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL326008 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL111126 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL110608 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL324433 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL107885 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL321207 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL108144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL111114 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109348 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL107838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL326204 | — | IC50 | > | 10000.0 | nM | - |