Assay Detail
Functional
CHEMBL809128
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In vitro inhibitory activity against pig liver microsomal squalene epoxidase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27885 | — | — | 1 | 7.70 |
| CHEMBL15929 | — | — | 1 | 7.70 |
| CHEMBL107546 | — | — | 1 | 7.52 |
| CHEMBL108692 | — | — | 1 | 7.52 |
| CHEMBL324433 | — | — | 1 | 7.22 |
| CHEMBL107568 | — | — | 1 | 7.16 |
| CHEMBL107608 | — | — | 1 | 7.16 |
| CHEMBL326008 | — | — | 1 | 7.16 |
| CHEMBL322059 | — | — | 1 | 7.05 |
| CHEMBL323953 | — | — | 1 | 7.00 |
| CHEMBL110608 | — | — | 1 | 6.92 |
| CHEMBL108144 | — | — | 1 | 6.89 |
| CHEMBL111126 | — | — | 1 | 6.82 |
| CHEMBL326241 | — | — | 1 | 6.82 |
| CHEMBL326204 | — | — | 1 | 6.68 |
| CHEMBL321207 | — | — | 1 | 6.40 |
| CHEMBL111114 | — | — | 1 | 6.06 |
| CHEMBL109348 | — | — | 1 | 6.00 |
| CHEMBL111684 | — | — | 1 | 6.00 |
| CHEMBL107838 | — | — | 1 | 5.52 |
| CHEMBL108867 | — | — | 1 | 5.30 |
| CHEMBL111609 | — | — | 1 | 5.30 |
| CHEMBL107810 | — | — | 1 | 5.10 |
| CHEMBL107885 | — | — | 1 | 5.10 |
| CHEMBL108047 | — | — | 1 | 5.00 |
| CHEMBL323395 | — | — | 1 | 4.70 |
| CHEMBL109936 | — | — | 1 | - |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27885 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL15929 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107546 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL108692 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL324433 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107568 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL107608 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL326008 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL322059 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL323953 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL110608 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL108144 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL111126 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL326241 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL326204 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL321207 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL111114 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL109348 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL111684 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL107838 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL108867 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL111609 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL107810 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL107885 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL108047 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL323395 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL109936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1144 | PRAVASTATIN | IC50 | > | 10000.0 | nM | - |