Compound Detail
CHEMBL111609
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CCN(C/C=C/C#CC(C)(C)C)Cc1cccc(OC[Si](C)(C)c2ccc(C(=O)C(F)(F)F)cc2)c1
Basic Information
| ChEMBL ID | CHEMBL111609 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | REWBWTJLLFPRHF-CSKARUKUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
515.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Squalene monooxygenase CHEMBL3592 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Squalene monooxygenase | IC50 | = | 5000.0 | nM | 5.3 | In vitro inhibitory activity against pig liver microsomal squalene epoxidase | 7650673 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7650673 | 10.1021/jm00017a004 | Squalene monooxygenase | 1 |
Data from ChEMBL 36 via Core Engine